Discuss This Drug

bictegravir

CHEBI:CHEBI_172943

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid with the amino group of 2,4,6-trifluorobenzylamine. It is a second-generation integrase strand transfer inhibitor (INSTI) and used (as its sodium salt) for the treatment of HIV-1.

Chemical Information

Molecular Formula
C21H18F3N3O5
Molecular Mass
449.386
Charge
0
SMILES
[H][C@@]12CC[C@@]([H])(C1)N1C(=O)C3=C(O)C(=O)C(=CN3C[C@@]1([H])O2)C(=O)NCC1=C(F)C=C(F)C=C1F
InChI
InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
InChIKey
SOLUWJRYJLAZCX-LYOVBCGYSA-N

Alternative Names

  • (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
  • bictegravir
  • bictegravirum
  • GS-9883
  • GS-9883-01

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1999660
oboInOwl#hasDbXref
Wikipedia:Bictegravir
core#notation
CHEBI:172943

Additional References

Wikipedia:Bictegravir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1999660
oboInOwl#hasDbXref
Wikipedia:Bictegravir
oboInOwl#id
CHEBI:172943
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
POWDER
marketing_start_date
20210227
labeler_name
PharmaChem Technologies G.B. Ltd.
generic_name
Bictegravir sodium, Emtricitabine, and Tenofovir Alafenamide Fumarate
brand_name
Biktarvy
brand_name_base
Biktarvy
product_ndc
68668-353
application_number
NDA210251
spl_id
b8e8eac7-9308-4d4c-a2c6-9fbf3b14edb8
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_67268
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_172960
core#notation
CHEBI:172943
active_ingredient_name
BICTEGRAVIR
rxcui
2584356
route
ORAL
active_ingredient_strength
1 kg/kg
package_marketing_start_date
27-FEB-21
unii
FWF6Q91TZO
nui
N0000009947
pharm_class_epc
Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
pharm_class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
pharm_class_moa
Nucleoside Reverse Transcriptase Inhibitors [MoA]
pharm_class_cs
Nucleosides [CS]
manufacturer_name
Gilead Sciences, Inc.
package_ndc
68668-353-01
package_description
25 kg in 1 DRUM (68668-353-01)
spl_set_id
0476d7eb-1024-4821-bbe7-abaacfda32a2
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect8707
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_172960
owl#annotatedSource
t134291
owl#someValuesFrom
t3263728