Hydrocortisone
CHEBI:CHEBI_17650
Definition
A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
Chemical Information
- Molecular Formula
- C21H30O5
- Molecular Mass
- 362.45990
- Charge
- 0
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
- InChI
- InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
- InChIKey
- JYGXADMDTFJGBT-VWUMJDOOSA-N
Alternative Names
- (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
- 11beta-hydrocortisone
- 11beta,17,21-trihydroxypregn-4-ene-3,20-dione
- 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
- 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
- 17-hydroxycorticosterone
- 4-pregnen-11beta,17alpha,21-triol-3,20-dione
- cortisol
- Cortisol
- hidrocortisona
- hydrocortisone
- Hydrocortisone
- hydrocortisonum
- Kendall's compound F
- Reichstein's substance M
Drug Classification
-
glucocorticoidView Class →
CHEBI:24261
-
20-oxo steroidView Class →
CHEBI:36885
-
21-hydroxy steroidView Class →
CHEBI:35344
-
17alpha-hydroxy-C21-steroidView Class →
CHEBI:138141
-
primary alpha-hydroxy ketoneView Class →
CHEBI:139590
-
tertiary alpha-hydroxy ketoneView Class →
CHEBI:139592
-
3-oxo-Delta(4) steroidView Class →
CHEBI:47909
-
11beta-hydroxy steroidView Class →
CHEBI:35346
-
t136562
-
t136591
-
t136934
-
t137051
-
t137560
-
t137564
-
t137658
-
t137803
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- oboInOwl#hasDbXref
- Wikipedia:Hydrocortisone
- DRON_00010000
- 5492
- core#notation
- CHEBI:17650
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- brand_name_base
- Poli-A
- brand_name
- Meijer Maximum Strength Anti-itch
- product_ndc
- 58624-0702
- generic_name
- Hydrocortisone Hydrogen Succinate
- dosage_form
- POULTICE
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- marketing_start_date
- 20240126
- listing_expiration_date
- 20241231
- spl_id
- b70b7624-efaa-48f9-b9fa-f84fdd5f874e
- labeler_name
- Artesa Labs, LLC
- oboInOwl#hasOBONamespace
- chebi_ontology
- oboInOwl#hasDbXref
- Wikipedia:Hydrocortisone
- DRON_00010000
- 5492
- oboInOwl#hasAlternativeId
- CHEBI:58221
- oboInOwl#id
- CHEBI:17650
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_77746
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#has_parent_hydride
- http://purl.obolibrary.org/obo/CHEBI_8386
- BFO_0000053
- http://purl.obolibrary.org/obo/DRON_00000060
- application_number
- ANDA211764
- package_ndc
- 61907-011-02
- has_treatment
- http://purl.obolibrary.org/obo/DOID_9749
- owl#someValuesFrom
- t696616
- route
- RECTAL
- package_description
- 1 TUBE in 1 CARTON (55910-504-16) / 56 g in 1 TUBE
- package_marketing_start_date
- 20040101
- manufacturer_name
- Walgreens
- rxcui
- 1494035
- owl#annotatedSource
- t137790
- spl_set_id
- e60473f7-fd00-a477-e053-2a95a90ad4dd
- upc
- 0307130560603
- active_ingredient_name
- HYDROCORTISONE SODIUM PHOSPHATE
- nui
- N0000175450
- active_ingredient_strength
- 1.12 g/100g
- unii
- 05RMF7YPWN
- brand_name_suffix
- Anti-Itch Maximum Strength
- core#notation
- CHEBI:17650
- pharm_class_moa
- Corticosteroid Hormone Receptor Agonists [MoA]
- pharm_class
- Corticosteroid [EPC]
- pharm_class_epc
- Corticosteroid [EPC]
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class