Discuss This Drug

sotorasib

CHEBI:CHEBI_178199

Definition

A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.

Chemical Information

Molecular Formula
C30H30F2N6O3
Molecular Mass
560.606
Charge
0
SMILES
CC(C)C1=NC=CC(C)=C1N1C(=O)N=C(N2CCN(C[C@@H]2C)C(=O)C=C)C2=C1N=C(C(F)=C2)C1=C(F)C=CC=C1O
InChI
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChIKey
NXQKSXLFSAEQCZ-SFHVURJKSA-N

Alternative Names

  • 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one
  • AMG 510
  • AMG-510
  • AMG510
  • Lumakras
  • sotorasib
  • sotorasibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2550714
oboInOwl#hasDbXref
Wikipedia:Sotorasib
core#notation
CHEBI:178199

Additional References

Wikipedia:Sotorasib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_5422
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect10377
owl#annotatedSource
t137868
owl#someValuesFrom
t3794490
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2550714
oboInOwl#hasDbXref
Wikipedia:Sotorasib
oboInOwl#id
CHEBI:178199
generic_name
Sotorasib
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
TABLET, COATED
marketing_start_date
20211117
package_marketing_start_date
06-MAR-20
labeler_name
Sigma Aldrich Corporation
brand_name
LUMAKRAS
brand_name_base
LUMAKRAS
product_ndc
58272-065
application_number
NDA214665
spl_id
26b7a962-2f7b-22b3-e063-6394a90a456d
package_ndc
58272-065-01
package_description
70 kg in 1 BAG (58272-065-01)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35610
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:178199
rxcui
2687207
active_ingredient_strength
1 kg/1
upc
0355513488020
manufacturer_name
Amgen Inc
active_ingredient_name
SOTORASIB
unii
2B2VM6UC8G
spl_set_id
c80a362c-7ac3-4894-a076-0691e68ef8c1
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class