palovarotene
CHEBI:CHEBI_188559
Definition
An olefinic compound that is ethene is which a hydrogen at position 1 is replaced by a 4-carboxyphenyl group and a hydrogen at position 2 is replaced by a 5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl group (the E-stereoisomer). It is a selective retinoic acid receptor gamma (RARgamma) agonist developed by Ipsen, to reduce the formation of new heterotopic ossification in adults and children with fibrodysplasia ossificans progressiva (FOP), a rare bone disorder.
Chemical Information
- Molecular Formula
- C27H30N2O2
- Molecular Mass
- 414.549
- Charge
- 0
- SMILES
- CC1(C)CCC(C)(C)C2=C1C=C(CN1C=CC=N1)C(\C=C\C1=CC=C(C=C1)C(O)=O)=C2
- InChI
- InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
- InChIKey
- YTFHCXIPDIHOIA-DHZHZOJOSA-N
Alternative Names
- 4-{(E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoic acid
- CLM 001
- CLM-001
- palovarotene
- palovaroteno
- palovarotenum
- R-667
- R667
- RG-667
- RO 3300074
- RO-3300074
- RO3300074
- Sohonos
Drug Classification
-
tetralinsView Class →
CHEBI:36786
-
processed material
-
benzoic acidsView Class →
CHEBI:22723
-
pyrazolesView Class →
CHEBI:26410
-
stilbenoidView Class →
CHEBI:26776
-
t144976
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- core#notation
- CHEBI:188559
- DRON_00010000
- 2663954
- oboInOwl#hasDbXref
- Wikipedia:Palovarotene
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- has_treatment
- http://purl.obolibrary.org/obo/DOID_13374
- owl#annotatedSource
- t145276
- owl#someValuesFrom
- t3991974
- core#notation
- CHEBI:188559
- active_ingredient_strength
- 1 kg/1
- nui
- M0018962
- pharm_class_epc
- Retinoid [EPC]
- pharm_class_cs
- Retinoids [CS]
- active_ingredient_name
- PALOVAROTENE
- rxcui
- 2663974
- unii
- 28K6I5M16G
- spl_set_id
- 67dce406-7cc4-4d66-92de-ad18b6df0625
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 2663954
- oboInOwl#hasDbXref
- Wikipedia:Palovarotene
- oboInOwl#id
- CHEBI:188559
- generic_name
- Palovarotene
- product_type
- DRUG FOR FURTHER PROCESSING
- marketing_category
- DRUG FOR FURTHER PROCESSING
- listing_expiration_date
- 20251231
- route
- ORAL
- dosage_form
- CAPSULE
- marketing_start_date
- 20230816
- package_marketing_start_date
- 22-AUG-22
- labeler_name
- Ipsen Biopharmaceuticals, Inc.
- product_ndc
- 15054-0050
- spl_id
- a370c8c8-9a5f-47df-b230-6ecbcc6dfa88
- package_ndc
- 15054-0050-1
- package_description
- 1 BLISTER PACK in 1 CARTON (15054-0050-1) / 14 CAPSULE in 1 BLISTER PACK
- brand_name
- SOHONOS
- brand_name_base
- SOHONOS
- application_number
- NDA215559
- manufacturer_name
- Ipsen Biopharmaceuticals, Inc.
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_88336
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR