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artemether

CHEBI:CHEBI_195280

Definition

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Chemical Information

Molecular Formula
C16H26O5
Molecular Mass
298.37460
Charge
0
SMILES
[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3
InChI
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey
SXYIRMFQILZOAM-HVNFFKDJSA-N

Alternative Names

  • (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine
  • 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
  • artemetero
  • artemether
  • artemetherum
  • artemisininelactol methyl ether
  • beta-artemether
  • beta-dihydroartemisinin methyl ether
  • dihydroartemisinin methyl ether
  • methyl-dihydroartemisinine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
18343
oboInOwl#hasDbXref
Wikipedia:Artemether
core#notation
CHEBI:195280

Additional References

Wikipedia:Artemether

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
18343
oboInOwl#hasDbXref
Wikipedia:Artemether
oboInOwl#id
CHEBI:195280
core#notation
CHEBI:195280
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38068
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_1395
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect10833
owl#annotatedSource
t145249
owl#someValuesFrom
t1010046