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artemether

CHEBI:CHEBI_195280

Definition

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Chemical Information

Molecular Formula
C16H26O5
Molecular Mass
298.37460
Charge
0
SMILES
[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3
InChI
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey
SXYIRMFQILZOAM-HVNFFKDJSA-N

Alternative Names

  • (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine
  • 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
  • artemetero
  • artemether
  • artemetherum
  • artemisininelactol methyl ether
  • beta-artemether
  • beta-dihydroartemisinin methyl ether
  • dihydroartemisinin methyl ether
  • methyl-dihydroartemisinine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:195280
DRON_00010000
18343
oboInOwl#hasDbXref
Wikipedia:Artemether

Additional References

Wikipedia:Artemether

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:195280
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
18343
oboInOwl#hasDbXref
Wikipedia:Artemether
oboInOwl#id
CHEBI:195280
rxcui
847734
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
active_ingredient_strength
25 kg/25kg
pharm_class_epc
Antimalarial [EPC]
pharm_class
Antimalarial [EPC]
marketing_start_date
20090407
labeler_name
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
manufacturer_name
Novartis Pharmaceuticals Corporation
nui
N0000175482
package_marketing_start_date
20090407
generic_name
Artemether
active_ingredient_name
LUMEFANTRINE
product_ndc
53104-7629
spl_id
6609b193-1909-4bb9-8027-7c1d540d54bf
package_ndc
53104-7629-1
package_description
25 kg in 1 DRUM (53104-7629-1)
brand_name
COARTEM
brand_name_base
COARTEM
application_number
NDA022268
unii
F38R0JR742
spl_set_id
7866ec19-dfac-47d4-a53f-511a12643cbf
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38068
has_treatment
http://purl.obolibrary.org/obo/DOID_1395
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect10833
owl#annotatedSource
t145249
owl#someValuesFrom
t1010046