Discuss This Drug

zuranolone

CHEBI:CHEBI_228302

Definition

A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.

Chemical Information

Molecular Formula
C25H35N3O2
Molecular Mass
409.574
Charge
0
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@](C)(O)CC[C@]4([H])[C@@]3([H])CC[C@]12C)C(=O)CN1C=C(C=N1)C#N
InChI
InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
InChIKey
HARRKNSQXBRBGZ-GVKWWOCJSA-N

Alternative Names

  • 1-(3alpha-hydroxy-3beta-methyl-20-oxo-5beta-19-norpregnan-21-yl)-1H-pyrazole-4-carbonitrile
  • 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile
  • BIIB-125
  • BIIB125
  • S-812217
  • SAGE 217
  • SAGE-217
  • SAGE217
  • SGE 797
  • SGE-797
  • zuranolone
  • zuranolonum
  • Zurzuvae

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2669905
oboInOwl#hasDbXref
Wikipedia:Zuranolone
core#notation
CHEBI:228302

Additional References

Wikipedia:Zuranolone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2669905
oboInOwl#hasDbXref
Wikipedia:Zuranolone
oboInOwl#id
CHEBI:228302
generic_name
ZURANOLONE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
dosage_form
CAPSULE
marketing_start_date
20231031
labeler_name
Biogen MA Inc.
product_ndc
11014-0492
spl_id
0990b4a3-440d-36d5-e063-6394a90a6c68
brand_name
ZURZUVAE
brand_name_base
ZURZUVAE
application_number
NDA217369
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50268
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:228302
rxcui
2669924
dea_schedule
CIV
active_ingredient_strength
1 kg/kg
pharm_class_moa
GABA A Receptor Positive Modulators [MoA]
pharm_class
Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator [EPC]
nui
N0000193997
pharm_class_epc
Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator [EPC]
package_marketing_start_date
31-OCT-23
active_ingredient_name
ZURANOLONE
package_ndc
11014-0492-1
package_description
1 BAG in 1 DRUM (11014-0492-1) / 100016 CAPSULE in 1 BAG
manufacturer_name
Biogen MA Inc.
unii
7ZW49N180B
spl_set_id
f18e53b0-d0bb-422d-8de7-ab64b7292b29
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_9478
owl#annotatedSource
t148800
owl#someValuesFrom
t4009936