Discuss This Drug

zuranolone

CHEBI:CHEBI_228302

Definition

A 3-hydroxy steroid that is 5beta-19-norpregnane substituted by hydroxy, methyl, oxo, and 4-cyano-1H-pyrazol-1-yl groups at positions 3, 3, 20 and 21, respectively. It is a positive allosteric modulator of GABAA receptor developed by Sage Therapeutics and Biogen for the treatment of postpartum depression in adults.

Chemical Information

Molecular Formula
C25H35N3O2
Molecular Mass
409.574
Charge
0
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@](C)(O)CC[C@]4([H])[C@@]3([H])CC[C@]12C)C(=O)CN1C=C(C=N1)C#N
InChI
InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
InChIKey
HARRKNSQXBRBGZ-GVKWWOCJSA-N

Alternative Names

  • 1-(3alpha-hydroxy-3beta-methyl-20-oxo-5beta-19-norpregnan-21-yl)-1H-pyrazole-4-carbonitrile
  • 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile
  • BIIB-125
  • BIIB125
  • S-812217
  • SAGE 217
  • SAGE-217
  • SAGE217
  • SGE 797
  • SGE-797
  • zuranolone
  • zuranolonum
  • Zurzuvae

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2669905
oboInOwl#hasDbXref
Wikipedia:Zuranolone
core#notation
CHEBI:228302

Additional References

Wikipedia:Zuranolone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_9478
owl#annotatedSource
t148800
owl#someValuesFrom
t4009936
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2669905
oboInOwl#hasDbXref
Wikipedia:Zuranolone
oboInOwl#id
CHEBI:228302
core#notation
CHEBI:228302
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50268
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class