Discuss This Drug

pirtobrutinib

CHEBI:CHEBI_229212

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-fluoro-2-methoxybenzoic acid with the amino group of 5-amino-3-[4-(aminomethyl)phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-pyrazole-4-carboxamide. It is a BTK inhibitor used for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

Chemical Information

Molecular Formula
C22H21F4N5O3
Molecular Mass
479.436
Charge
0
SMILES
COC1=C(C=C(F)C=C1)C(=O)NCC1=CC=C(C=C1)C1=NN([C@@H](C)C(F)(F)F)C(N)=C1C(N)=O
InChI
InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6-13)10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3,(H2,28,32)(H,29,33)/t11-/m0/s1
InChIKey
FWZAWAUZXYCBKZ-NSHDSACASA-N

Alternative Names

  • 5-amino-3-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-pyrazole-4-carboxamide
  • Jaypirca
  • LOXO 305
  • LOXO-305
  • LY 3527727
  • LY-3527727
  • LY3527727
  • pirtobrutinib
  • pirtobrutinibum
  • RXC-005
  • RXC005

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:229212
DRON_00010000
2629338
oboInOwl#hasDbXref
Wikipedia:Pirtobrutinib

Additional References

Wikipedia:Pirtobrutinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:229212
pharm_class_moa
Bruton's Tyrosine Kinase Inhibitors [MoA]
pharm_class
Bruton's Tyrosine Kinase Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2629338
oboInOwl#hasDbXref
Wikipedia:Pirtobrutinib
oboInOwl#id
CHEBI:229212
generic_name
pirtobrutinib
rxcui
2629353
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
listing_expiration_date
20251231
route
ORAL
active_ingredient_strength
50 mg/1
nui
N0000193934
dosage_form
TABLET, COATED
pharm_class_epc
Kinase Inhibitor [EPC]
labeler_name
Eli Lilly and Company
manufacturer_name
Eli Lilly and Company
marketing_start_date
20230127
package_marketing_start_date
20230215
brand_name
JAYPIRCA
brand_name_base
JAYPIRCA
product_ndc
0002-7026
application_number
NDA216059
spl_id
c1e8b6db-e92d-4ee1-a21e-f1e494690ee4
active_ingredient_name
PIRTOBRUTINIB
package_ndc
0002-7026-99
package_description
30 TABLET, COATED in 1 BOTTLE (0002-7026-99)
unii
JNA39I7ZVB
spl_set_id
bd551845-0878-49a4-860f-839b83f6b801
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76617
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
owl#annotatedSource
t148817
owl#someValuesFrom
t3979076