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fruquintinib

CHEBI:CHEBI_229221

Definition

A member of the class of quinazolines that is quinazoline substituted by [2-methyl-3-(methylcarbamoyl)-1-benzofuran-6-yl]oxy, methoxy, and methoxy groups at positions 4, 6, and 7, respectively. It is a highly potent and selective inhibitor of VEGFR 1, 2 and 3 (IC50 = 33, 0.35, and 35 nM) used for the treatment of metastatic colorectal cancer.

Chemical Information

Molecular Formula
C21H19N3O5
Molecular Mass
393.399
Charge
0
SMILES
CNC(=O)C1=C(C)OC2=C1C=CC(OC1=NC=NC3=C1C=C(OC)C(OC)=C3)=C2
InChI
InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
InChIKey
BALLNEJQLSTPIO-UHFFFAOYSA-N

Alternative Names

  • 6-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide
  • fruquintinib
  • fruquintinibum
  • Fruzaqla
  • HMPL-013

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2670179
oboInOwl#hasDbXref
Wikipedia:Fruquintinib
core#notation
CHEBI:229221

Additional References

Wikipedia:Fruquintinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2670179
oboInOwl#hasDbXref
Wikipedia:Fruquintinib
oboInOwl#id
CHEBI:229221
generic_name
Fruquintinib
brand_name
Fruzaqla
brand_name_base
Fruzaqla
rxcui
2670198
product_type
DRUG FOR FURTHER PROCESSING
marketing_category
DRUG FOR FURTHER PROCESSING
listing_expiration_date
20251231
route
ORAL
dosage_form
CAPSULE
active_ingredient_strength
1 mg/1
marketing_start_date
20231108
package_marketing_start_date
08-NOV-23
labeler_name
HUTCHMED International Corporation
manufacturer_name
Takeda Pharmaceuticals America, Inc.
product_ndc
63020-210
spl_id
40d93ebc-3bb1-4829-8bbf-1d428b14edc9
active_ingredient_name
FRUQUINTINIB
package_ndc
63020-210-21
package_description
1 BOTTLE in 1 CARTON (63020-210-21) / 21 CAPSULE in 1 BOTTLE
application_number
NDA217564
unii
49DXG3M5ZW
spl_set_id
186d786e-dc8a-45f2-b5e1-01ac0201879f
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_65207
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
core#notation
CHEBI:229221
has_treatment
http://purl.obolibrary.org/obo/DOID_1990
owl#annotatedSource
t148818
owl#someValuesFrom
t4010194