Discuss This Drug

etrasimod

CHEBI:CHEBI_229230

Definition

An organic heterotricyclic compound that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by carboxymethyl and [4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy groups at positions 3R and 7, respectively. It is a potent and functional antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50 = 1.88 nM in CHO cells).

Chemical Information

Molecular Formula
C26H26F3NO3
Molecular Mass
457.493
Charge
0
SMILES
OC(=O)C[C@H]1CCC2=C1NC1=C2C=C(OCC2=CC(=C(C=C2)C2CCCC2)C(F)(F)F)C=C1
InChI
InChI=1S/C26H26F3NO3/c27-26(28,29)22-11-15(5-8-19(22)16-3-1-2-4-16)14-33-18-7-10-23-21(13-18)20-9-6-17(12-24(31)32)25(20)30-23/h5,7-8,10-11,13,16-17,30H,1-4,6,9,12,14H2,(H,31,32)/t17-/m1/s1
InChIKey
MVGWUTBTXDYMND-QGZVFWFLSA-N

Alternative Names

  • (R)-2-(7-((4-cyclopentyl-3-(trifluoromethyl)benzyl)oxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
  • [(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
  • APD 334
  • APD-334
  • APD334
  • etrasimod
  • etrasimodum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2668045
oboInOwl#hasDbXref
Wikipedia:Etrasimod
core#notation
CHEBI:229230

Additional References

Wikipedia:Etrasimod

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2668045
oboInOwl#hasDbXref
Wikipedia:Etrasimod
oboInOwl#id
CHEBI:229230
core#notation
CHEBI:229230
generic_name
etrasimod
rxcui
2668057
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
listing_expiration_date
20251231
route
ORAL
dosage_form
TABLET, FILM COATED
active_ingredient_strength
2 mg/1
pharm_class
Sphingosine 1-phosphate Receptor Modulator [EPC]
marketing_start_date
20231019
package_marketing_start_date
20231019
labeler_name
U.S. Pharmaceuticals
manufacturer_name
U.S. Pharmaceuticals
brand_name
Velsipity
brand_name_base
Velsipity
product_ndc
0069-0274
application_number
NDA216956
spl_id
5269b1d1-a4c8-4680-aeb5-fd3772f2c573
active_ingredient_name
ETRASIMOD ARGININE
package_ndc
0069-0274-30
package_description
1 BOTTLE in 1 CARTON (0069-0274-30) / 30 TABLET, FILM COATED in 1 BOTTLE
unii
MXE5EMA09L
spl_set_id
65171e4a-d136-4abc-b08c-c40c1b486ff6
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_144998
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_229232
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_229232
owl#annotatedSource
t148794
owl#someValuesFrom
t4010669