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bromfenac

CHEBI:CHEBI_240107

Definition

Amfenac in which the the hydrogen at the 4 position of the benzoyl group is substituted by bromine. It is used for the management of ocular pain and treatment of postoperative inflammation in patients who have undergone cataract extraction. It was withdrawn from the US market in 1998, following concerns over off-label abuse and hepatic failure.

Chemical Information

Molecular Formula
C15H12BrNO3
Molecular Mass
334.16500
Charge
0
SMILES
Nc1c(CC(O)=O)cccc1C(=O)c1ccc(Br)cc1
InChI
InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
InChIKey
ZBPLOVFIXSTCRZ-UHFFFAOYSA-N

Alternative Names

  • [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
  • [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
  • 2-amino-3-(4-bromobenzoyl)benzeneacetic acid
  • bromfenac
  • bromfenaco
  • bromfenacum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
19737
oboInOwl#hasDbXref
Wikipedia:Bromfenac
core#notation
CHEBI:240107

Additional References

Wikipedia:Bromfenac

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_marketing_start_date
03-JUL-19
package_description
1 POUCH in 1 CARTON (49708-755-41) / 1 BOTTLE, DROPPER in 1 POUCH / 5 mL in 1 BOTTLE, DROPPER
package_ndc
68180-434-01
listing_expiration_date
20241231
marketing_start_date
20100210
route
OPHTHALMIC
labeler_name
Regis Technologies Inc
spl_id
eabaf212-8ed0-4b4e-a3df-f41aa5d0681b
application_number
NDA203168
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
19737
oboInOwl#hasDbXref
Wikipedia:Bromfenac
generic_name
Bromfenac Sodium Hydrate
brand_name
bromfenac 0.075%
brand_name_base
Bromfenac Ophthalmic Solution, 0.07%
oboInOwl#id
CHEBI:240107
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
SOLUTION/ DROPS
product_ndc
49708-755
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_75915
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35481
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_59175
core#notation
CHEBI:240107
rxcui
1375922
pharm_class
Non-Steroidal [CS]
active_ingredient_strength
.76 mg/mL
manufacturer_name
Alembic Pharmaceuticals Inc.
active_ingredient_name
BROMFENAC
unii
8ECV571Y37
spl_set_id
7d723a00-4822-4e04-aa22-21de22009d0a
upc
0372485649716
brand_name_suffix
0.075%
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113663
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect11260
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_59175
owl#annotatedSource
t148801
owl#someValuesFrom
t735595