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Edrophonium

CHEBI:CHEBI_251408

Definition

A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

Chemical Information

Molecular Formula
C10H16NO
Molecular Mass
166.24010
Charge
+1
SMILES
CC[N+](C)(C)c1cccc(O)c1
InChI
InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
InChIKey
VWLHWLSRQJQWRG-UHFFFAOYSA-O

Alternative Names

  • (3-hydroxyphenyl)dimethylethylammonium
  • 3-hydroxy-N,N-dimethyl-N-ethylanilinium
  • edrophonium
  • Edrophonium
  • EDROPHONIUM
  • EDROPHONIUM ION
  • Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium
  • N-ethyl-3-hydroxy-N,N-dimethylanilinium
  • N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3752
oboInOwl#hasDbXref
PMID:7488499
core#notation
CHEBI:251408

Additional References

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Additional Attributes

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chebi_ontology
DRON_00010000
3752
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CHEBI:251408
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CHEBI:251408
oboInOwl#hasAlternativeId
CHEBI:4758
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_37733
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http://www.w3.org/2002/07/owl#Class
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https://w3id.org/def/predibionto#has_side_effect11436
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