Discuss This Drug

Amifostine

CHEBI:CHEBI_2636

Definition

An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.

Chemical Information

Molecular Formula
C5H15N2O3PS
Molecular Mass
214.22404
Charge
0
SMILES
NCCCNCCSP(O)(O)=O
InChI
InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChIKey
JKOQGQFVAUAYPM-UHFFFAOYSA-N

Alternative Names

  • amifostina
  • amifostine
  • Amifostine
  • amifostinum
  • Ethyol
  • S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:2636
DRON_00010000
4126
oboInOwl#hasDbXref
Wikipedia:Amifostine

Additional References

Wikipedia:Amifostine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22586
core#notation
CHEBI:2636
active_ingredient_strength
1 kg/kg
package_marketing_start_date
08-DEC-95
active_ingredient_name
AMIFOSTINE
package_description
1 BAG in 1 DRUM (60269-275-01) / 10 kg in 1 BAG
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
4126
generic_name
AMIFOSTINE
oboInOwl#hasDbXref
Wikipedia:Amifostine
oboInOwl#id
CHEBI:2636
listing_expiration_date
20241231
marketing_start_date
19951208
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
labeler_name
Zach System S.A.
product_ndc
46439-8768
spl_id
09f6adc4-4342-4ced-a666-c0b585af8d58
package_ndc
46439-8768-1
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_17141
has_treatment
http://purl.obolibrary.org/obo/DOID_5786
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111302
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect11761
owl#annotatedSource
t155658
owl#someValuesFrom
t2996364