Discuss This Drug

Cisplatin

CHEBI:CHEBI_27899

Definition

A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).

Chemical Information

Molecular Formula
H6Cl2N2Pt
Molecular Mass
300.04452
Charge
0
SMILES
[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]
InChI
InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChIKey
LXZZYRPGZAFOLE-UHFFFAOYSA-L

Alternative Names

  • (SP-4-2)-diamminedichloridoplatinum
  • (SP-4-2)-diamminedichloroplatinum
  • [PtCl2(NH3)2]
  • Briplatin
  • CDDP
  • cis-[PtCl2(NH3)2]
  • cis-DDP
  • cis-diamminedichloridoplatinum(II)
  • cis-diamminedichloroplatinum
  • cis-diamminedichloroplatinum(II)
  • cis-Diamminedichloroplatinum(II)
  • cis-diammineplatinum(II) dichloride
  • cis-dichlorodiammineplatinum(II)
  • cis-platin
  • Cismaplat
  • cisplatin
  • Cisplatin
  • cisplatine
  • cisplatino
  • cisplatinum
  • Lederplatin
  • Neoplatin
  • Peyrone's chloride
  • Peyrone's salt
  • Platamine
  • Platinex
  • Platinol
  • Randa

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:27899
DRON_00010000
2555
oboInOwl#hasDbXref
Wikipedia:Cisplatin

Additional References

Wikipedia:Cisplatin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
marketing_start_date
20001107
route
INTRAVENOUS
labeler_name
Heraeus Precious Metals GmbH & Co. KG
spl_id
06fba021-72dc-3cfe-e063-6394a90a570c
package_ndc
49452-2078-4
application_number
ANDA074656
product_ndc
50711-0001
core#notation
CHEBI:27899
pharm_class
Platinum-based Drug [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2555
oboInOwl#hasDbXref
Wikipedia:Cisplatin
oboInOwl#hasAlternativeId
CHEBI:3722
oboInOwl#id
CHEBI:27899
generic_name
CISplatin
brand_name
CISplatin
brand_name_base
CISplatin
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50684
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rxcui
1736854
package_marketing_start_date
16-FEB-95
active_ingredient_strength
50 mg/50mL
nui
N0000175073
pharm_class_epc
Platinum-based Drug [EPC]
manufacturer_name
FOSUN PHARMA USA INC
active_ingredient_name
CISPLATIN
package_description
25 g in 1 BOTTLE, GLASS (49452-2078-4)
unii
Q20Q21Q62J
spl_set_id
a440f077-46f6-4688-a209-65bce38d1c92
upc
0360505627905
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113538
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect13989
owl#annotatedSource
t162745
has_treatment
http://purl.obolibrary.org/obo/DOID_2876
owl#someValuesFrom
t2909239