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Trioxsalen

CHEBI:CHEBI_28329

Definition

7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

Chemical Information

Molecular Formula
C14H12O3
Molecular Mass
228.24328
Charge
0
SMILES
Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1
InChI
InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
InChIKey
FMHHVULEAZTJMA-UHFFFAOYSA-N

Alternative Names

  • 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
  • 2',4,8-Trimethylpsoralen
  • 4,5',8-Trimethylpsoralen
  • 4,8,5'-Trimethylpsoralen
  • 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
  • Trimethylpsoralen
  • trioxisaleno
  • Trioxsalen
  • trioxysalen
  • Trioxysalen
  • trioxysalene
  • trioxysalenum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
10844
oboInOwl#hasDbXref
Wikipedia:Trioxsalen
core#notation
CHEBI:28329

Additional References

Wikipedia:Trioxsalen

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
10844
oboInOwl#hasDbXref
Wikipedia:Trioxsalen
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CHEBI:20282
oboInOwl#id
CHEBI:28329
core#notation
CHEBI:28329
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_47868
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
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t162762
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t700857