Vincristine
CHEBI:CHEBI_28445
Definition
A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical Information
- Molecular Formula
- C46H56N4O10
- Molecular Mass
- 824.95780
- Charge
- 0
- SMILES
- [H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC
- InChI
- InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
- InChIKey
- OGWKCGZFUXNPDA-XQKSVPLYSA-N
Alternative Names
- (+)-Vincristine
- 22-oxo-vincaleukoblastine
- 22-oxovincaleukoblastine
- 22-Oxovincaleukoblastine
- leucristine
- leurocristine
- oncovin
- vincristin
- Vincristine
- vinkristin
Treatment Applications
-
paranasal sinus lymphomaView Disease →
DOID:1355
Drug Classification
-
methyl esterView Class →
CHEBI:25248
-
tertiary alcoholView Class →
CHEBI:26878
-
organic heterotetracyclic compoundView Class →
CHEBI:38163
-
tertiary amino compoundView Class →
CHEBI:50996
-
organic heteropentacyclic compoundView Class →
CHEBI:38164
-
acetate esterView Class →
CHEBI:47622
-
formamidesView Class →
CHEBI:24079
-
vinca alkaloidView Class →
CHEBI:27288
-
t164960
-
t165612
-
t165931
-
t166231
-
t166310
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 11202
- oboInOwl#hasDbXref
- Wikipedia:Vincristine
- core#notation
- CHEBI:28445
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_76924
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 11202
- oboInOwl#hasDbXref
- Wikipedia:Vincristine
- oboInOwl#hasAlternativeId
- CHEBI:9987
- oboInOwl#id
- CHEBI:28445
- product_type
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- marketing_category
- BULK INGREDIENT
- dosage_form
- INJECTION, SOLUTION
- marketing_start_date
- 20150618
- route
- INTRAVENOUS
- package_marketing_start_date
- 18-JUN-15
- labeler_name
- Minakem High Potent SA
- generic_name
- Vincristine Sulphate
- brand_name
- VinCRIStine Sulfate
- brand_name_base
- VinCRIStine Sulfate
- product_ndc
- 69910-0003
- application_number
- ANDA071484
- spl_id
- 5194d693-f479-47c1-ac87-88aa5647771b
- package_ndc
- 69910-0003-0
- package_description
- 600 g in 1 CONTAINER (69910-0003-0)
- chebi#has_parent_hydride
- http://purl.obolibrary.org/obo/CHEBI_27375
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_143658
- core#notation
- CHEBI:28445
- rxcui
- 1863354
- active_ingredient_strength
- 210 g/210g
- pharm_class
- Vinca Alkaloids [CS]
- active_ingredient_name
- VINCRISTINE SULFATE
- manufacturer_name
- Hospira, Inc.
- unii
- T5IRO3534A
- spl_set_id
- b22e4c8e-dbe1-4d4b-a026-e1812974071c
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_3253
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_108564
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect6510
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_143658
- owl#someValuesFrom
- t638372
- owl#annotatedSource
- t166320