Discuss This Drug

Vincristine

CHEBI:CHEBI_28445

Definition

A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.

Chemical Information

Molecular Formula
C46H56N4O10
Molecular Mass
824.95780
Charge
0
SMILES
[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC
InChI
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
InChIKey
OGWKCGZFUXNPDA-XQKSVPLYSA-N

Alternative Names

  • (+)-Vincristine
  • 22-oxo-vincaleukoblastine
  • 22-oxovincaleukoblastine
  • 22-Oxovincaleukoblastine
  • leucristine
  • leurocristine
  • oncovin
  • vincristin
  • Vincristine
  • vinkristin

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
11202
oboInOwl#hasDbXref
Wikipedia:Vincristine
core#notation
CHEBI:28445

Additional References

Wikipedia:Vincristine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76924
has_treatment
http://purl.obolibrary.org/obo/DOID_3253
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
11202
oboInOwl#hasDbXref
Wikipedia:Vincristine
oboInOwl#hasAlternativeId
CHEBI:9987
oboInOwl#id
CHEBI:28445
product_type
BULK INGREDIENT
listing_expiration_date
20241231
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
marketing_start_date
20150618
route
INTRAVENOUS
package_marketing_start_date
18-JUN-15
labeler_name
Minakem High Potent SA
generic_name
Vincristine Sulphate
brand_name
VinCRIStine Sulfate
brand_name_base
VinCRIStine Sulfate
product_ndc
69910-0003
application_number
ANDA071484
spl_id
5194d693-f479-47c1-ac87-88aa5647771b
package_ndc
69910-0003-0
package_description
600 g in 1 CONTAINER (69910-0003-0)
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_27375
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_143658
core#notation
CHEBI:28445
rxcui
1863354
active_ingredient_strength
210 g/210g
pharm_class
Vinca Alkaloids [CS]
active_ingredient_name
VINCRISTINE SULFATE
manufacturer_name
Hospira, Inc.
unii
T5IRO3534A
spl_set_id
b22e4c8e-dbe1-4d4b-a026-e1812974071c
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_108564
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect6510
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_143658
owl#someValuesFrom
t638372
owl#annotatedSource
t166320