Discuss This Drug

Vincristine

CHEBI:CHEBI_28445

Definition

A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.

Chemical Information

Molecular Formula
C46H56N4O10
Molecular Mass
824.95780
Charge
0
SMILES
[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC
InChI
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
InChIKey
OGWKCGZFUXNPDA-XQKSVPLYSA-N

Alternative Names

  • (+)-Vincristine
  • 22-oxo-vincaleukoblastine
  • 22-oxovincaleukoblastine
  • 22-Oxovincaleukoblastine
  • leucristine
  • leurocristine
  • oncovin
  • vincristin
  • Vincristine
  • vinkristin

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
11202
oboInOwl#hasDbXref
Wikipedia:Vincristine
core#notation
CHEBI:28445

Additional References

Wikipedia:Vincristine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
11202
oboInOwl#hasDbXref
Wikipedia:Vincristine
oboInOwl#hasAlternativeId
CHEBI:9987
oboInOwl#id
CHEBI:28445
core#notation
CHEBI:28445
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_27375
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61951
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_143658
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3253
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_108564
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect6510
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_143658
owl#someValuesFrom
t638372
owl#annotatedSource
t166320