Discuss This Drug

Chlorambucil

CHEBI:CHEBI_28830

Definition

A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Chemical Information

Molecular Formula
C14H19Cl2NO2
Molecular Mass
304.21160
Charge
0
SMILES
OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl
InChI
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N

Alternative Names

  • 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid
  • 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
  • 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
  • Ambochlorin
  • Chlorambucil
  • CHLORAMBUCIL
  • chloraminophen
  • gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
  • Leukeran
  • N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
  • phenylbutyric acid nitrogen mustard

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:28830
DRON_00010000
2346
oboInOwl#hasDbXref
Wikipedia:Chlorambucil

Additional References

Wikipedia:Chlorambucil

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:28830
active_ingredient_name
CHLORAMBUCIL
rxcui
105553
active_ingredient_strength
1 kg/kg
package_marketing_start_date
28-DEC-19
pharm_class_moa
Alkylating Activity [MoA]
pharm_class
Alkylating Drug [EPC]
pharm_class_epc
Alkylating Drug [EPC]
nui
N0000175558
manufacturer_name
Woodward Pharma Services LLC
package_description
25 kg in 1 DRUM (76055-0025-1)
unii
18D0SL7309
spl_set_id
e3d7a0f9-d704-4676-b16e-622ff6d22aa2
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2346
oboInOwl#hasDbXref
Wikipedia:Chlorambucil
oboInOwl#hasAlternativeId
CHEBI:48770
oboInOwl#id
CHEBI:28830
generic_name
CHLORAMBUCIL
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
marketing_start_date
20191228
labeler_name
AMERICAN PACIFIC CORPORATION
product_ndc
69784-610
spl_id
3f5cf902-16b6-45d9-8949-37e87cdd0e2e
package_ndc
69784-610-25
brand_name
LEUKERAN
brand_name_base
LEUKERAN
application_number
NDA010669
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_88188
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_12029
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect14723
owl#annotatedSource
t166357
owl#someValuesFrom
t875520