Discuss This Drug

benazepril

CHEBI:CHEBI_3011

Definition

A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.

Chemical Information

Molecular Formula
C24H28N2O5
Molecular Mass
424.48950
Charge
0
SMILES
CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O
InChI
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
InChIKey
XPCFTKFZXHTYIP-PMACEKPBSA-N

Alternative Names

  • [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
  • 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
  • benazepril
  • Benazepril
  • benazeprilum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:3011
DRON_00010000
18867
oboInOwl#hasDbXref
Wikipedia:Benazepril

Additional References

Wikipedia:Benazepril

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
marketing_start_date
19910621
spl_id
27039572-2e0b-f4b2-e063-6394a90adc97
labeler_name
AX Pharmaceutical Corp
package_description
90 TABLET in 1 BOTTLE (62135-719-90)
package_ndc
51655-066-52
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
TABLET, COATED
application_number
NDA019851
product_ndc
62559-414
route
ORAL
has_treatment
http://purl.obolibrary.org/obo/DOID_0070370
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect15258
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_88201
owl#annotatedSource
t173291
owl#someValuesFrom
t1040525
active_ingredient_name
BENAZEPRIL HYDROCHLORIDE
active_ingredient_strength
50 kg/50kg
nui
M0471776
upc
0368071513004
spl_set_id
6d24bcc1-e5f4-4d65-9858-5fc583efe572
rxcui
898721
manufacturer_name
REMEDYREPACK INC.
unii
N1SN99T69T
package_marketing_start_date
25-DEC-23
core#notation
CHEBI:3011
pharm_class_epc
Thiazide Diuretic [EPC]
pharm_class
Decreased Blood Pressure [PE]
pharm_class_pe
Increased Diuresis [PE]
pharm_class_cs
Thiazides [CS]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
18867
generic_name
Benazepril Hydrochloride and Hydrochlorothiazide
brand_name
Lotensin
brand_name_base
Lotensin
oboInOwl#hasDbXref
Wikipedia:Benazepril
oboInOwl#id
CHEBI:3011
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723853
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_88200
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_88201