Discuss This Drug

crotamiton

CHEBI:CHEBI_31439

Definition

An enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred.

Chemical Information

Molecular Formula
C13H17NO
Molecular Mass
203.28020
Charge
0
SMILES
CCN(C(=O)C=CC)c1ccccc1C
InChI
InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3
InChIKey
DNTGGZPQPQTDQF-UHFFFAOYSA-N

Alternative Names

  • crotalgin
  • crotamiton
  • crotamitone
  • crotamitonum
  • crotonyl-N-ethyl-o-toluidine
  • N-ethyl-N-(2-methylphenyl)but-2-enamide
  • N-ethyl-o-crotonotoluidide

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
21766
oboInOwl#hasDbXref
Patent:GB615137
core#notation
CHEBI:31439

Additional References

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Additional Attributes

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chebi_ontology
DRON_00010000
21766
oboInOwl#hasDbXref
Patent:GB615137
oboInOwl#id
CHEBI:31439
core#notation
CHEBI:31439
rxcui
2049603
product_type
BULK INGREDIENT
listing_expiration_date
20251231
marketing_category
BULK INGREDIENT
route
TOPICAL
dosage_form
LOTION
active_ingredient_strength
1 kg/kg
marketing_start_date
20220115
package_marketing_start_date
31-JUL-18
labeler_name
Marnel Pharmaceuticals, Inc.
generic_name
Crotamiton
brand_name
Crotan
brand_name_base
Crotan
product_ndc
48581-310
application_number
ANDA087204
manufacturer_name
Marnel Pharmaceuticals, Inc.
spl_id
2484fc6d-3d1b-7425-e063-6394a90a0e9d
active_ingredient_name
CROTAMITON
package_ndc
48581-310-55
package_description
23 kg in 1 DRUM (48581-310-55)
unii
D6S4O4XD0H
spl_set_id
6f7478fa-ed2b-4943-9d40-1fd0161a0854
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_73333
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