Droxidopa

CHEBI:CHEBI_31524

Definition

A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension

Chemical Information

Molecular Formula: C9H11NO5
Molecular Mass: 213.18730
Charge: 0
SMILES: N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(O)=O
InChI: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKey: QXWYKJLNLSIPIN-JGVFFNPUSA-N

Alternative Names

(-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid
(2S,3R)-3,4-dihydroxy-phenylserine
(betaR)-beta,3-dihydroxy-L-tyrosine
Dops
droxidopa
droxidopum
Droxydopa
L-Dihydroxyphenylserine
L-DOPS
L-threo-dihydroxyphenylserine
L-Threodops
Northera
SM 5688
threo-Dopaserine

Treatment Applications

obsolete soldiers heart
DOID:0050533

View Disease →
postural orthostatic tachycardia syndrome
DOID:0111154

View Disease →

Drug Classification

catechols
CHEBI:33566

View Class →
L-tyrosine derivative
CHEBI:27177

View Class →
t179084
t179442
t179678

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

core#notation: CHEBI:31524
DRON_00010000: 1489913
oboInOwl#hasDbXref: Wikipedia:Droxidopa

Additional References

Wikipedia:Droxidopa

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date: 20241231
dosage_form: CAPSULE
marketing_start_date: 20210924
labeler_name: Sumitomo Pharma Co., Ltd.
application_number: ANDA211652
spl_id: 1bde3200-7ff0-5d78-e063-6294a90ad5f1
product_ndc: 70771-1609
core#notation: CHEBI:31524
pharm_class: Increased Blood Pressure [PE]
pharm_class_cs: Catecholamines [CS]
pharm_class_pe: Increased Blood Pressure [PE]
upc: 0327241201905
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
rxcui: 1490040
active_ingredient_strength: 40 kg/1
package_marketing_start_date: 30-APR-14
nui: N0000178478
manufacturer_name: Slate Run Pharmaceuticals, LLC
active_ingredient_name: DROXIDOPA
unii: J7A92W69L7
spl_set_id: 81b798dc-b8dc-48a5-af46-82bb55f789a8
package_description: 90 CAPSULE in 1 BOTTLE (0904-7393-89)
oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 1489913
oboInOwl#hasDbXref: Wikipedia:Droxidopa
oboInOwl#id: CHEBI:31524
generic_name: DROXIDOPA
brand_name: DROXIDOPA
brand_name_base: DROXIDOPA
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_50266
route: ORAL
package_ndc: 42973-237-00
has_treatment: http://purl.obolibrary.org/obo/DOID_0090145
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_105487
owl#annotatedSource: t180318
owl#someValuesFrom: t2990256