idebenone
CHEBI:CHEBI_31687
Definition
A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Chemical Information
- Molecular Formula
- C19H30O5
- Molecular Mass
- 338.444
- Charge
- 0
- SMILES
- COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O
- InChI
- InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
- InChIKey
- JGPMMRGNQUBGND-UHFFFAOYSA-N
Alternative Names
- 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
- 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
- 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
- 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone
- 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
- 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone
- CV 2619
- CV-2619
- idebenona
- idebenone
- idebenonum
- Raxone
Treatment Applications
-
Athabaskan brainstem dysgenesis syndromeView Disease →
DOID:0050682
-
cerebellar ataxiaView Disease →
DOID:0050753
-
spinocerebellar ataxia type 1View Disease →
DOID:0050954
-
spinocerebellar ataxia type 2View Disease →
DOID:0050955
-
spinocerebellar ataxia type 6View Disease →
DOID:0050956
-
spinocerebellar ataxia type 4View Disease →
DOID:0050957
-
spinocerebellar ataxia type 7View Disease →
DOID:0050958
-
spinocerebellar ataxia type 10View Disease →
DOID:0050960
-
spinocerebellar ataxia type 11View Disease →
DOID:0050961
-
spinocerebellar ataxia type 14View Disease →
DOID:0050964
-
spinocerebellar ataxia type 15View Disease →
DOID:0050965
-
spinocerebellar ataxia type 18View Disease →
DOID:0050969
-
spinocerebellar ataxia type 20View Disease →
DOID:0050971
-
spinocerebellar ataxia type 25View Disease →
DOID:0050974
-
spinocerebellar ataxia type 26View Disease →
DOID:0050975
-
spinocerebellar ataxia type 28View Disease →
DOID:0050977
-
spinocerebellar ataxia type 29View Disease →
DOID:0050978
-
spinocerebellar ataxia type 30View Disease →
DOID:0050979
-
spinocerebellar ataxia type 34View Disease →
DOID:0050981
-
spinocerebellar ataxia type 36View Disease →
DOID:0050983
-
spinocerebellar ataxia type 37View Disease →
DOID:0050984
-
spinocerebellar ataxia type 38View Disease →
DOID:0050985
-
GRID2-related spinocerebellar ataxiaView Disease →
DOID:0050988
-
episodic ataxia type 2View Disease →
DOID:0050990
-
episodic ataxia type 5View Disease →
DOID:0050993
-
episodic ataxia type 6View Disease →
DOID:0050994
-
amyotrophic lateral sclerosis type 6View Disease →
DOID:0060198
-
amyotrophic lateral sclerosis type 10View Disease →
DOID:0060201
-
amyotrophic lateral sclerosis type 15View Disease →
DOID:0060206
-
acrodermatitis chronica atrophicansView Disease →
DOID:0060344
-
ataxia with oculomotor apraxia type 3View Disease →
DOID:0060557
-
hypomyelinating leukodystrophy 7View Disease →
DOID:0060794
-
Prieto syndromeView Disease →
DOID:0060805
-
Niemann-Pick disease type AView Disease →
DOID:0070111
-
Niemann-Pick disease type BView Disease →
DOID:0070112
-
Niemann-Pick disease type C1View Disease →
DOID:0070113
-
hypomyelinating leukodystrophy 15View Disease →
DOID:0070398
-
hypomyelinating leukodystrophy 24View Disease →
DOID:0070406
-
spinocerebellar ataxia 44View Disease →
DOID:0080286
-
spinocerebellar ataxia 45View Disease →
DOID:0080287
-
spinocerebellar ataxia 46View Disease →
DOID:0080288
-
hypomyelinating leukodystrophy 14View Disease →
DOID:0080296
-
sporadic amyotrophic lateral sclerosisView Disease →
DOID:0080917
-
bilateral frontoparietal polymicrogyriaView Disease →
DOID:0080922
-
Sandestig-Stefanova syndromeView Disease →
DOID:0081272
-
neuronal intranuclear inclusion diseaseView Disease →
DOID:0081294
-
ataxia-oculomotor apraxia type 4View Disease →
DOID:0081383
-
ataxia-telangiectasia-like disorder-1View Disease →
DOID:0081384
-
ataxia-telangiectasia-like disorder-2View Disease →
DOID:0081385
-
primary progressive aphasiaView Disease →
DOID:0081388
-
Dyggve-Melchior-Clausen diseaseView Disease →
DOID:0111167
-
cerebellar diseaseView Disease →
DOID:2786
-
cerebral amyloid angiopathyView Disease →
DOID:9246
-
neuronal ceroid lipofuscinosis 4View Disease →
DOID:0110720
-
Joubert syndrome 15View Disease →
DOID:0110984
-
Friedreich ataxia 1View Disease →
DOID:0111218
-
Friedreich ataxia 2View Disease →
DOID:0111219
-
cerebellar ataxia type 9View Disease →
DOID:0111747
-
Friedreich ataxiaView Disease →
DOID:12705
-
Pick's diseaseView Disease →
DOID:11870
-
Creutzfeldt-Jakob diseaseView Disease →
DOID:11949
-
Lewy body dementiaView Disease →
DOID:12217
Drug Classification
-
1,4-benzoquinonesView Class →
CHEBI:132124
-
primary alcoholView Class →
CHEBI:15734
-
t179767
-
t180021
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 51296
- oboInOwl#hasDbXref
- Wikipedia:Idebenone
- core#notation
- CHEBI:31687
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 51296
- oboInOwl#hasDbXref
- Wikipedia:Idebenone
- oboInOwl#id
- CHEBI:31687
- core#notation
- CHEBI:31687
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_22586
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_111562
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect17314
- has_treatment
- http://purl.obolibrary.org/obo/DOID_5678
- owl#annotatedSource
- t180274
- owl#someValuesFrom
- t917810