lopinavir
CHEBI:CHEBI_31781
Definition
A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir.
Chemical Information
- Molecular Formula
- C37H48N4O5
- Molecular Mass
- 628.80080
- Charge
- 0
- SMILES
- CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)Cc1ccccc1
- InChI
- InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
- InChIKey
- KJHKTHWMRKYKJE-SUGCFTRWSA-N
Alternative Names
- (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
- Lopinavir
Drug Classification
-
dicarboxylic acid diamideView Class →
CHEBI:35779
-
amphetaminesView Class →
CHEBI:35338
-
t179212
-
t179308
-
t179780
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 195088
- oboInOwl#hasDbXref
- Reaxys:9309881
- core#notation
- CHEBI:31781
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- listing_expiration_date
- 20241231
- route
- ORAL
- package_marketing_start_date
- 18-JUN-10
- manufacturer_name
- NuCare Pharmaceuticals,Inc.
- marketing_start_date
- 20180925
- spl_id
- 738a5989-96cc-422d-a5e7-cd389deb335d
- package_ndc
- 12613-6799-9
- package_description
- 13700 TABLET, FILM COATED in 1 CARTON (12613-6799-9)
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 195088
- oboInOwl#hasDbXref
- Reaxys:9309881
- oboInOwl#id
- CHEBI:31781
- generic_name
- Lopinavir and ritonavir
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- dosage_form
- SOLUTION
- labeler_name
- AbbVie Deutschland GmbH & Co Kg
- product_ndc
- 12613-6799
- brand_name
- Lopinavir and ritonavir
- brand_name_base
- Lopinavir and ritonavir
- application_number
- ANDA204739
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_35660
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect17415
- owl#annotatedSource
- t180173
- owl#someValuesFrom
- t986023
- core#notation
- CHEBI:31781
- rxcui
- 847749
- active_ingredient_strength
- 50 kg/50kg
- pharm_class_moa
- UDP Glucuronosyltransferases Inducers [MoA]
- pharm_class
- UDP Glucuronosyltransferases Inducers [MoA]
- nui
- N0000190117
- active_ingredient_name
- LOPINAVIR
- pharm_class_epc
- Protease Inhibitor [EPC]
- unii
- O3J8G9O825
- spl_set_id
- a7072c60-6dbf-4125-95e7-497c05a9e6a6
- upc
- 0342385933604
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class