Tacalcitol
CHEBI:CHEBI_32176
Definition
A hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp.
Chemical Information
- Molecular Formula
- C27H44O3
- Molecular Mass
- 416.646
- Charge
- 0
- SMILES
- [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CC[C@@H](O)C(C)C
- InChI
- InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
- InChIKey
- BJYLYJCXYAMOFT-RSFVBTMBSA-N
Alternative Names
- (1alpha,24R)-1,24-dihydroxyvitamin D3
- (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
- 1-alpha,24(R)-dihydroxyvitamin D3
- Bonalfa
- PRI 2191
- PRI-2191
- tacalcitol
- tacalcitolum
- TV 02
- TV-02
Treatment Applications
-
keratosis palmoplantaris striata 1View Disease →
DOID:0081108
-
limited sclerodermaView Disease →
DOID:1577
Drug Classification
-
secondary alcoholView Class →
CHEBI:35681
-
D3 vitaminsView Class →
CHEBI:73558
-
seco-cholestaneView Class →
CHEBI:36818
-
t182735
-
t182749
-
t183144
-
t183410
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 291204
- oboInOwl#hasDbXref
- Wikipedia:Tacalcitol
- core#notation
- CHEBI:32176
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_109352
- has_treatment
- http://purl.obolibrary.org/obo/DOID_6498
- owl#annotatedSource
- t183867
- owl#someValuesFrom
- t568613
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 291204
- oboInOwl#hasDbXref
- Wikipedia:Tacalcitol
- oboInOwl#id
- CHEBI:32176
- core#notation
- CHEBI:32176
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_50748
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#has_functional_parent
- http://purl.obolibrary.org/obo/CHEBI_28940
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class