Discuss This Drug

tibolone

CHEBI:CHEBI_32223

Definition

Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.

Chemical Information

Molecular Formula
C21H28O2
Molecular Mass
312.44580
Charge
0
SMILES
[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])[C@H](C)CC1=C2CCC(=O)C1
InChI
InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1
InChIKey
WZDGZWOAQTVYBX-XOINTXKNSA-N

Alternative Names

  • (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
  • (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one
  • 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one
  • 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one
  • tibolona
  • tibolone
  • tibolonum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
38260
oboInOwl#hasDbXref
Patent:US3475465
core#notation
CHEBI:32223

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
38260
oboInOwl#hasDbXref
Patent:US3475465
oboInOwl#id
CHEBI:32223
core#notation
CHEBI:32223
listing_expiration_date
20241231
dosage_form
POWDER
marketing_start_date
20110708
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
labeler_name
SHAKTI LIFESCIENCE PRIVATE LIMITED
package_marketing_start_date
08-JUL-11
generic_name
Tibolone Micronized Ph. Eur.
active_ingredient_name
TIBOLONE
product_ndc
24002-0033
spl_id
997cb01b-f827-405f-9257-28eea5032fc3
package_ndc
24002-0033-0
package_description
5 kg in 1 BAG (24002-0033-0)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_51060
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_13958
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect19266
owl#annotatedSource
t187133
owl#someValuesFrom
t688071