Discuss This Drug

tolvaptan

CHEBI:CHEBI_32246

Definition

A benzazepine derivative incorporating a benzenedicarboxamide function whch is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. Tolvaptan is a racemate consisting of a 1:1 mixture of 5R and 5S stereomers.

Chemical Information

Molecular Formula
C26H25ClN2O3
Molecular Mass
448.950
Charge
0
SMILES
CC1=CC=CC=C1C(=O)NC1=CC(C)=C(C=C1)C(=O)N1CCCC(O)C2=CC(Cl)=CC=C12
InChI
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChIKey
GYHCTFXIZSNGJT-UHFFFAOYSA-N

Alternative Names

  • jinarc
  • N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
  • OPC 41061
  • OPC-41061
  • samsca
  • tolvaptan
  • Tolvaptan

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:32246
DRON_00010000
358257
oboInOwl#hasDbXref
Wikipedia:Tolvaptan

Additional References

Wikipedia:Tolvaptan

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:32246
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
358257
oboInOwl#hasDbXref
Wikipedia:Tolvaptan
oboInOwl#id
CHEBI:32246
generic_name
Tolvaptan Povidone Premix
brand_name
JYNARQUE
brand_name_base
JYNARQUE
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
labeler_name
TYCHE INDUSTRIES LIMITED
product_ndc
60862-008
application_number
ANDA216949
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_59680
rxcui
2274816
active_ingredient_strength
4.61 kg/4.61kg
package_marketing_start_date
28-DEC-13
manufacturer_name
Ascend Laboratories, LLC
active_ingredient_name
TOLVAPTAN
unii
21G72T1950
spl_set_id
92ce12f1-eae0-4c83-9a4e-a5181e08fa92
nui
N0000193178
upc
0372205131118
pharm_class_epc
Vasopressin V2 Receptor Antagonist [EPC]
pharm_class
Vasopressin V2 Receptor Antagonists [MoA]
pharm_class_moa
Vasopressin V2 Receptor Antagonists [MoA]
package_description
50 kg in 1 DRUM (14501-0085-2)
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20131228
spl_id
be0b9a28-8443-4f19-a200-5f10622d1fdf
package_ndc
60862-008-06
has_treatment
http://purl.obolibrary.org/obo/DOID_0060977
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111938
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect19379
owl#annotatedSource
t187151
owl#someValuesFrom
t1009728