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Verteporfin

CHEBI:CHEBI_32293

Definition

An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.

Alternative Names

  • trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
  • trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester
  • trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
  • trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester
  • verteporfin
  • Visudyne

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
118886
oboInOwl#hasDbXref
Reaxys:13501141
core#notation
CHEBI:32293

Additional References

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
118886
oboInOwl#hasDbXref
Reaxys:13501141
oboInOwl#id
CHEBI:32293
core#notation
CHEBI:32293
brand_name
Visudyne
brand_name_base
Visudyne
rxcui
351914
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
listing_expiration_date
20251231
active_ingredient_strength
15 mg/1
route
INTRAVENOUS
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
package_marketing_start_date
20000412
labeler_name
Bausch Health US LLC
manufacturer_name
Bausch Health US LLC
marketing_start_date
20000412
pharm_class_moa
Photoabsorption [MoA]
pharm_class
Photoenhancer [EPC]
pharm_class_pe
Photosensitizing Activity [PE]
nui
N0000175540
generic_name
verteporfin for injection
product_ndc
24208-560
application_number
NDA021119
spl_id
f48ec619-2eda-4360-9c67-bb79bdd00353
active_ingredient_name
VERTEPORFIN
package_ndc
24208-560-15
package_description
1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 CARTON (24208-560-15)
unii
0X9PA28K43
spl_set_id
2f0a34ce-3c57-4ac8-b28e-512be807272f
upc
0301875600150
pharm_class_epc
Photoenhancer [EPC]
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_88230
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_60779
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_0060259
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https://w3id.org/def/predibionto#has_drug_113812
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t187197
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t3103606