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Carbidopa

CHEBI:CHEBI_3395

Definition

The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.

Chemical Information

Molecular Formula
C10H16N2O5
Molecular Mass
244.24440
Charge
0
SMILES
O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O
InChI
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChIKey
QTAOMKOIBXZKND-PPHPATTJSA-N

Alternative Names

  • (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
  • (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate
  • (S)-(-)-carbidopa hydrate
  • (S)-carbidopa hydrate
  • carbidopa
  • carbidopa hydrate
  • carbidopa monohydrate
  • carbidopum monohydricum
  • L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Patent:US3462536
DRON_00010000
2019
core#notation
CHEBI:3395

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Patent:US3462536
DRON_00010000
2019
generic_name
CARBIDOPA MONOHYDRATE
brand_name
SINEMET
brand_name_base
SINEMET
oboInOwl#hasAlternativeId
CHEBI:212626
oboInOwl#id
CHEBI:3395
product_ndc
51927-2480
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_48560
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_39585
package_ndc
51927-2480-0
rxcui
2690292
manufacturer_name
REMEDYREPACK INC.
package_marketing_start_date
15-DEC-20
route
ORAL
spl_id
a51379dd-c47a-4fcd-aed0-5f19c18bf12c
product_type
BULK INGREDIENT
dosage_form
TABLET, ORALLY DISINTEGRATING
package_description
100 TABLET in 1 BOTTLE (70710-1723-1)
listing_expiration_date
20241231
marketing_start_date
20201215
active_ingredient_strength
52.5 mg/1
active_ingredient_name
LEVODOPA
unii
46627O600J
spl_set_id
ef0be743-e6f3-4662-8b0c-53f1eda4638a
nui
M0370111
upc
0362756518889
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
labeler_name
Teva API India Limited
application_number
ANDA209910
pharm_class
Aromatic [CS]
core#notation
CHEBI:3395
pharm_class_epc
Aromatic Amino Acid [EPC]
pharm_class_moa
DOPA Decarboxylase Inhibitors [MoA]
pharm_class_cs
Amino Acids, Aromatic [CS]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0060963
owl#annotatedSource
t193750
owl#someValuesFrom
t2995969