Discuss This Drug

mevastatin

CHEBI:CHEBI_34848

Definition

A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.

Chemical Information

Molecular Formula
C23H34O5
Molecular Mass
390.51310
Charge
0
SMILES
CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
InChI
InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChIKey
AJLFOPYRIVGYMJ-INTXDZFKSA-N

Alternative Names

  • (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
  • antibiotic ML 236B
  • Compactin
  • CS 500
  • mevastatin
  • mevastatin
  • Mevastatin
  • mevastatina
  • mevastatine
  • mevastatinum
  • ML 236 B
  • ML-236B

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Mevastatin
core#notation
CHEBI:34848

Additional References

Wikipedia:Mevastatin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_40303
owl#annotatedSource
t197344
owl#someValuesFrom
t214084
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Mevastatin
oboInOwl#id
CHEBI:34848
core#notation
CHEBI:34848
generic_name
Mevastatin
listing_expiration_date
20251231
dosage_form
POWDER
marketing_start_date
20040329
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
labeler_name
Zhejiang Hisun Pharmaceutical Co., Ltd.
package_marketing_start_date
29-MAR-04
product_ndc
58623-0077
spl_id
eacf1fdd-4350-48ad-e053-2995a90a20a4
active_ingredient_name
MEVASTATIN
package_ndc
58623-0077-7
package_description
25 kg in 1 DRUM (58623-0077-7)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76964
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http://purl.obolibrary.org/obo/chebi#3_STAR
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http://www.w3.org/2002/07/owl#Class