BETAHISTINE
CHEBI:CHEBI_35677
Definition
An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
Chemical Information
- Molecular Formula
- C8H12N2
- Molecular Mass
- 136.19430
- Charge
- 0
- SMILES
- CNCCc1ccccn1
- InChI
- InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
- InChIKey
- UUQMNUMQCIQDMZ-UHFFFAOYSA-N
Alternative Names
- [2-(2-pyridyl)ethyl]methylamine
- 2-(beta-methylaminoethyl)pyridine
- 2-[2-(methylamino)ethyl]pyridine
- betahistina
- betahistine
- betahistinum
- N-methyl-2-(2-pyridinyl)ethanamine
- N-methyl-2-pyridin-2-ylethanamine
- N-methyl-2-pyridineethanamine
Treatment Applications
-
enlarged vestibular aqueductView Disease →
DOID:0050332
-
nonsyndromic deafnessView Disease →
DOID:0050563
-
episodic ataxia type 3View Disease →
DOID:0050991
-
drug-induced hearing lossView Disease →
DOID:0070310
-
superior semicircular canal dehiscenceView Disease →
DOID:0080193
-
inner ear diseaseView Disease →
DOID:2952
-
vestibular diseaseView Disease →
DOID:3426
-
middle ear diseaseView Disease →
DOID:5100
-
X-linked deafness 2View Disease →
DOID:0111737
-
sensorineural hearing lossView Disease →
DOID:10003
-
otorrheaView Disease →
DOID:10261
-
middle ear cholesterol granulomaView Disease →
DOID:10852
-
chronic tympanitisView Disease →
DOID:11217
-
adhesive otitis mediaView Disease →
DOID:11235
-
obsolete nerve deafnessView Disease →
DOID:12113
-
tympanosclerosisView Disease →
DOID:1214
-
otosclerosisView Disease →
DOID:12185
-
obsolete hearing diseaseView Disease →
DOID:12226
-
viral labyrinthitisView Disease →
DOID:12357
-
vestibulocochlear nerve diseaseView Disease →
DOID:12657
-
vestibular neuronitisView Disease →
DOID:12683
-
acoustic neuromaView Disease →
DOID:12689
-
submandibular gland diseaseView Disease →
DOID:12897
-
obsolete nasopharyngeal diphtheriaView Disease →
DOID:13309
-
active cochlear Meniere's diseaseView Disease →
DOID:13492
-
acute tympanitisView Disease →
DOID:13790
-
trochlear nerve diseaseView Disease →
DOID:13864
-
focal labyrinthitisView Disease →
DOID:13867
-
vestibular nystagmusView Disease →
DOID:14070
-
toxic labyrinthitisView Disease →
DOID:14081
-
bilateral hyperactive labyrinthView Disease →
DOID:14165
-
labyrinthitisView Disease →
DOID:1468
-
retrocochlear diseaseView Disease →
DOID:2889
-
labyrinthine dysfunctionView Disease →
DOID:566
-
tympanic membrane diseaseView Disease →
DOID:5782
-
peripheral vertigoView Disease →
DOID:9847
-
Meniere's diseaseView Disease →
DOID:9849
-
obsolete labyrinthine diseaseView Disease →
DOID:4539
-
postauricular lymphadenitisView Disease →
DOID:4638
-
middle ear cancerView Disease →
DOID:5099
-
inner ear cancerView Disease →
DOID:5102
-
cochlear diseaseView Disease →
DOID:5463
-
internal auditory canal lipomaView Disease →
DOID:6752
-
endolymphatic hydropsView Disease →
DOID:9848
-
chronic canaliculitisView Disease →
DOID:9936
Drug Classification
-
secondary amino compoundView Class →
CHEBI:50995
-
aminoalkylpyridineView Class →
CHEBI:38198
-
t199869
-
t199978
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1511
- oboInOwl#hasDbXref
- Wikipedia:Betahistine
- core#notation
- CHEBI:35677
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- has_treatment
- http://purl.obolibrary.org/obo/DOID_13490
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1511
- oboInOwl#hasDbXref
- Wikipedia:Betahistine
- oboInOwl#id
- CHEBI:35677
- core#notation
- CHEBI:35677
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_71173
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_113887
- owl#annotatedSource
- t200894
- owl#someValuesFrom
- t3011096