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Chlorothiazide

CHEBI:CHEBI_3640

Definition

4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.

Chemical Information

Molecular Formula
C7H6ClN3O4S2
Molecular Mass
295.72300
Charge
0
SMILES
NS(=O)(=O)c1cc2c(NC=NS2(=O)=O)cc1Cl
InChI
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChIKey
JBMKAUGHUNFTOL-UHFFFAOYSA-N

Alternative Names

  • 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
  • 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • chlorothiazide
  • Chlorothiazide
  • chlorothiazidum
  • clorotiazida

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:3640
oboInOwl#hasDbXref
Wikipedia:Chlorothiazide
DRON_00010000
2396

Additional References

Wikipedia:Chlorothiazide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:3640
pharm_class
Thiazides [CS]
pharm_class_pe
Increased Diuresis [PE]
pharm_class_cs
Thiazides [CS]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
213439
listing_expiration_date
20241231
route
INTRAVENOUS
nui
M0471776
pharm_class_epc
Thiazide Diuretic [EPC]
package_marketing_start_date
19620215
active_ingredient_strength
500 mg/18mL
manufacturer_name
Salix Pharmaceuticals, Inc
spl_id
e19fe503-9b2e-4db0-b4ee-0fb9ec9c11c2
active_ingredient_name
CHLOROTHIAZIDE
package_ndc
68083-614-01
package_description
1 VIAL in 1 CARTON (68083-614-01) / 18 mL in 1 VIAL
unii
77W477J15H
spl_set_id
bf921935-9740-458e-b786-69f76d8ad139
marketing_start_date
20160825
upc
0368083614010
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Chlorothiazide
DRON_00010000
2396
oboInOwl#hasAlternativeId
CHEBI:162615
oboInOwl#id
CHEBI:3640
generic_name
Chlorothiazide sodium
brand_name
Chlorothiazide sodium
brand_name_base
Chlorothiazide sodium
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
labeler_name
Salix Pharmaceuticals, Inc
product_ndc
68083-614
application_number
ANDA218630
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35674
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000059
has_treatment
http://purl.obolibrary.org/obo/DOID_0081328
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect21620
owl#annotatedSource
t204143
owl#someValuesFrom
t2992574