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Clemastine

CHEBI:CHEBI_3738

Definition

2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.

Chemical Information

Molecular Formula
C21H26ClNO
Molecular Mass
343.89000
Charge
0
SMILES
[H][C@@]1(CCCN1C)CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1
InChI
InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1
InChIKey
YNNUSGIPVFPVBX-NHCUHLMSSA-N

Alternative Names

  • (+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
  • (+)-(2R)-2-[2-[[(R)-p-chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
  • (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
  • clemastina
  • clemastine
  • Clemastine
  • clemastinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Clemastine
DRON_00010000
2578
core#notation
CHEBI:3738

Additional References

Wikipedia:Clemastine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Clemastine
DRON_00010000
2578
oboInOwl#id
CHEBI:3738
oboInOwl#hasAlternativeId
CHEBI:569763
product_type
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
SYRUP
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
marketing_start_date
19920401
labeler_name
Sekisui Medical Co., Ltd.
generic_name
CLEMASTINE FUMARATE
brand_name
CLEMASTINE FUMARATE
brand_name_base
CLEMASTINE FUMARATE
product_ndc
55152-001
application_number
ANDA074884
spl_id
1497c98e-a5ec-492a-b739-007de6837747
package_ndc
55152-001-01
package_description
500 g in 1 CAN (55152-001-01)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_37955
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723854
core#notation
CHEBI:3738
rxcui
857461
active_ingredient_strength
2.68 mg/1
package_marketing_start_date
19920401
manufacturer_name
Ayurax, LLC
active_ingredient_name
CLEMASTINE FUMARATE
unii
19259EGQ3D
spl_set_id
5c99e7af-86a5-4c17-82d5-2d4119e4fe72
upc
0300930308017
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_0060488
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https://w3id.org/def/predibionto#has_side_effect22470
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t207686
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