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Clofazimine

CHEBI:CHEBI_3749

Definition

3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.

Chemical Information

Molecular Formula
C27H22Cl2N4
Molecular Mass
473.39600
Charge
0
SMILES
CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc2cc1Nc1ccc(Cl)cc1
InChI
InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3
InChIKey
WDQPAMHFFCXSNU-UHFFFAOYSA-N

Alternative Names

  • (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine
  • 3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine
  • 3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin
  • clofazimina
  • clofazimine
  • clofaziminum
  • N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine
  • N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2592
oboInOwl#hasDbXref
PMID:3279207
core#notation
CHEBI:3749

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2592
oboInOwl#hasDbXref
PMID:3279207
oboInOwl#hasAlternativeId
CHEBI:355347
oboInOwl#id
CHEBI:3749
core#notation
CHEBI:3749
generic_name
Clofazimine micronized
listing_expiration_date
20241231
dosage_form
POWDER
marketing_start_date
20230303
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
labeler_name
Derivados Quimicos
package_marketing_start_date
02-MAR-23
product_ndc
59349-0030
spl_id
f5faff8d-aeba-5473-e053-2995a90a9f7d
active_ingredient_name
CLOFAZIMINE
package_ndc
59349-0030-0
package_description
1 BAG in 1 DRUM (59349-0030-0) / 1 BAG in 1 BAG / 25 kg in 1 BAG
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_37958
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6045
owl#annotatedSource
t207711
owl#someValuesFrom
t845421