Discuss This Drug

Clozapine

CHEBI:CHEBI_3766

Definition

A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.

Chemical Information

Molecular Formula
C18H19ClN4
Molecular Mass
326.824
Charge
0
SMILES
N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C
InChI
InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChIKey
QZUDBNBUXVUHMW-UHFFFAOYSA-N

Alternative Names

  • 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • Clozapin
  • clozapina
  • clozapine
  • Clozapine
  • clozapinum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Clozapine
DRON_00010000
2626
core#notation
CHEBI:3766

Additional References

Wikipedia:Clozapine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_description
100 TABLET in 1 BOTTLE (69809-0126-5)
package_ndc
71554-025-01
rxcui
104776
manufacturer_name
HLS Therapeutics (USA), Inc.
package_marketing_start_date
20050819
unii
J60AR2IKIC
spl_set_id
90876802-0e3a-44c9-9ff7-1754dfbe736a
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Clozapine
DRON_00010000
2626
oboInOwl#id
CHEBI:3766
generic_name
CLOZAPINE
brand_name
Clozaril
brand_name_base
Clozaril
product_type
BULK INGREDIENT
dosage_form
TABLET, ORALLY DISINTEGRATING
product_ndc
69809-0126
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_37887
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20050819
labeler_name
HLS Therapeutics (USA), Inc.
application_number
NDA019758
spl_id
fc60ce01-7b51-45da-b044-d869b4e15824
core#notation
CHEBI:3766
active_ingredient_strength
75 kg/75kg
nui
N0000175430
pharm_class_epc
Atypical Antipsychotic [EPC]
pharm_class
Atypical Antipsychotic [EPC]
active_ingredient_name
CLOZAPINE
upc
0369809012653
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_778
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_101962
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect22802
owl#annotatedSource
t207321
owl#someValuesFrom
t3004287