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Atazanavir

CHEBI:CHEBI_37924

Definition

A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV).

Chemical Information

Molecular Formula
C38H52N6O7
Molecular Mass
704.85550
Charge
0
SMILES
COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(cc1)-c1ccccn1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
InChI
InChI=1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1
InChIKey
AXRYRYVKAWYZBR-GASGPIRDSA-N

Alternative Names

  • atazanavir
  • atazanavirum
  • ATZ
  • dimethyl (3S,8S,9S,12S)-9-benzyl-3,12-di-tert-butyl-8-hydroxy-4,11-dioxo-6-[4-(2-pyridyl)benzyl]-2,5,6,10,13-pentaazatetradecanedioate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:37924
oboInOwl#hasDbXref
Wikipedia:Atazanavir
DRON_00010000
343047

Additional References

Wikipedia:Atazanavir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:37924
pharm_class
P-Glycoprotein Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Atazanavir
DRON_00010000
343047
generic_name
atazanavir and cobicistat
brand_name
EVOTAZ
brand_name_base
EVOTAZ
oboInOwl#id
CHEBI:37924
product_type
BULK INGREDIENT
marketing_category
EXPORT ONLY
dosage_form
CAPSULE, GELATIN COATED
product_ndc
65015-678
application_number
NDA206353
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35660
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
package_description
100 kg in 1 DRUM (65015-678-61)
package_ndc
17337-0009-1
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20150129
labeler_name
Zydus Pharmaceuticals USA Inc.
spl_id
7e699ffb-f6bd-4e26-8c38-869f41cf7b56
rxcui
1601660
active_ingredient_strength
50 mg/kg
pharm_class_moa
Organic Anion Transporting Polypeptide 1B3 Inhibitors [MoA]
nui
N0000190108
package_marketing_start_date
11-JUN-18
manufacturer_name
Zydus Pharmaceuticals USA Inc.
active_ingredient_name
COBICISTAT
unii
4MT4VIE29P
pharm_class_epc
Cytochrome P450 3A Inhibitor [EPC]
spl_set_id
83db29d7-5d85-49d6-8cb6-740473365cf8
upc
0370710105235
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111129
owl#annotatedSource
t207594
owl#someValuesFrom
t3000922