Discuss This Drug

fluvastatin

CHEBI:CHEBI_38561

Definition

A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.

Chemical Information

Molecular Formula
C24H26FNO4
Molecular Mass
411.467
Charge
0
SMILES
C1(=CC=C(C=C1)C=2C=3C(N(C2/C=C/[C@@H](C[C@@H](CC(O)=O)O)O)C(C)C)=CC=CC3)F
InChI
InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1
InChIKey
FJLGEFLZQAZZCD-JUFISIKESA-N

Alternative Names

  • (+-)-fluvastatin
  • (6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
  • Cranoc
  • erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid
  • fluvastatin
  • fluvastatina
  • fluvastatine
  • fluvastatinum
  • rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
  • rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
  • rac-(3R,5S)-fluvastatin

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:38561
oboInOwl#hasDbXref
Wikipedia:Fluvastatin
DRON_00010000
41127

Additional References

Wikipedia:Fluvastatin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
687048
listing_expiration_date
20241231
route
ORAL
package_marketing_start_date
20120705
manufacturer_name
Mylan Pharmaceuticals Inc.
marketing_start_date
20210507
spl_id
b37d7bf2-b2f1-4843-b49b-1fde982a0f4a
package_ndc
72162-1034-1
package_description
100 CAPSULE in 1 BOTTLE (72162-1034-1)
unii
PYF7O1FV7F
spl_set_id
ccd6bbe1-e293-4e1c-9ec4-e6c217612e77
core#notation
CHEBI:38561
active_ingredient_strength
1 kg/kg
pharm_class
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
brand_name_suffix
XL
active_ingredient_name
FLUVASTATIN SODIUM
upc
0300937443018
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Fluvastatin
DRON_00010000
41127
oboInOwl#id
CHEBI:38561
generic_name
Fluvastatin sodium Amorphous
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
TABLET, FILM COATED, EXTENDED RELEASE
labeler_name
Mylan Pharmaceuticals Inc.
product_ndc
72162-1034
brand_name_base
Fluvastatin Sodium
brand_name
FLUVASTATIN SODIUM ER
application_number
ANDA209397
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_77255
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_5136
has_treatment
http://purl.obolibrary.org/obo/DOID_4207
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_109787
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect23125
owl#annotatedSource
t211047
owl#someValuesFrom
t2911851