Discuss This Drug

Cosyntropin

CHEBI:CHEBI_3901

Definition

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

Chemical Information

Molecular Formula
C136H210N40O31S
Molecular Mass
2933.43700
Charge
0
SMILES
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(O)=O
InChI
InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChIKey
ZOEFCCMDUURGSE-SQKVDDBVSA-N

Alternative Names

  • adrenocorticotropic hormone 1-24
  • alpha(1-24)-corticotrophin
  • ATCH (1-24)
  • beta(1-24)-corticotrophin
  • corticotropin-(1-24)
  • corticotropin-(1-24) tetracosapeptide
  • Cosyntropin
  • SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro
  • SYSMEHFRWGKPVGKKRRPVKVYP
  • tetracosactide
  • L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyline

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:3901
DRON_00010000
2890
oboInOwl#hasDbXref
KEGG:D00284

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:3901
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2890
oboInOwl#hasDbXref
KEGG:D00284
oboInOwl#id
CHEBI:3901
generic_name
COSYNTROPIN
brand_name
COSYNTROPIN
brand_name_base
COSYNTROPIN
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
route
INTRAVENOUS
labeler_name
HF Acquisition Co LLC, DBA HealthFirst
manufacturer_name
HF Acquisition Co LLC, DBA HealthFirst
package_marketing_start_date
28-MAY-12
active_ingredient_strength
.25 mg/mL
marketing_start_date
20120528
nui
N0000175941
pharm_class_epc
Adrenocorticotropic Hormone [EPC]
pharm_class
Adrenocorticotropic Hormone [CS]
pharm_class_cs
Adrenocorticotropic Hormone [CS]
application_number
ANDA202147
active_ingredient_name
COSYNTROPIN
unii
72YY86EA29
product_ndc
63557-2071
spl_id
1c309a8b-b2cc-ed56-e063-6394a90a890a
package_ndc
63557-2071-1
package_description
100 g in 1 BOTTLE, GLASS (63557-2071-1)
spl_set_id
15eaaab2-d656-7310-e063-6394a90ae59f
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_33295
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112847
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect23200
owl#annotatedSource
t210928
owl#someValuesFrom
t571281