Discuss This Drug

Lovastatin

CHEBI:CHEBI_40303

Definition

A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).

Chemical Information

Molecular Formula
C24H36O5
Molecular Mass
404.53964
Charge
0
SMILES
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChIKey
PCZOHLXUXFIOCF-BXMDZJJMSA-N

Alternative Names

  • (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
  • 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
  • 6alpha-methylcompactin
  • lovastatin
  • Lovastatin
  • LOVASTATIN
  • Mevacor
  • Mevinolin
  • MK-803
  • ML-530B

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6472
oboInOwl#hasDbXref
Wikipedia:Lovastatin
core#notation
CHEBI:40303

Additional References

Wikipedia:Lovastatin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6472
oboInOwl#hasDbXref
Wikipedia:Lovastatin
oboInOwl#hasAlternativeId
CHEBI:6544
oboInOwl#id
CHEBI:40303
generic_name
LOVASTATIN
brand_name
Altoprev
brand_name_base
Altoprev
product_ndc
71335-0882
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_9150
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
TABLET, EXTENDED RELEASE
labeler_name
LIVZON NEW NORTH RIVER PHARMACEUTICAL CO.,LTD.
marketing_start_date
20140624
spl_id
11bdeeb2-f87f-43f9-88d8-7ad0ded01186
application_number
NDA021316
package_description
30 TABLET in 1 BOTTLE (71335-0819-1)
package_ndc
50090-3881-2
route
ORAL
core#notation
CHEBI:40303
rxcui
997007
manufacturer_name
Carlsbad Technology, Inc.
package_marketing_start_date
01-APR-06
active_ingredient_name
LOVASTATIN
active_ingredient_strength
100 kg/100kg
nui
N0000000121
pharm_class_epc
HMG-CoA Reductase Inhibitor [EPC]
pharm_class
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
pharm_class_moa
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
unii
9LHU78OQFD
spl_set_id
030c0f79-6bb5-4876-bf8e-b7a25b25dd38
upc
0355289881308
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_14502
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect23475
owl#annotatedSource
t214494
owl#someValuesFrom
t2999146