Discuss This Drug

Dantrolene

CHEBI:CHEBI_4317

Definition

The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

Chemical Information

Molecular Formula
C14H10N4O5
Molecular Mass
314.257
Charge
0
SMILES
C1(NC(=O)CN1N=C(C=2OC(C=3C=CC([N+]([O-])=O)=CC3)=CC2)[H])=O
InChI
InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)
InChIKey
OZOMQRBLCMDCEG-UHFFFAOYSA-N

Alternative Names

  • 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin
  • 1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
  • dantrolene
  • Dantrolene
  • dantroleno
  • dantrolenum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3105
oboInOwl#hasDbXref
PMID:8797628
core#notation
CHEBI:4317

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3105
oboInOwl#hasDbXref
PMID:8797628
oboInOwl#id
CHEBI:4317
generic_name
dantrolene sodium
brand_name
Dantrium
brand_name_base
Dantrium
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, FOR SOLUTION
product_ndc
63629-2170
application_number
NDA018264
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_146223
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_59697
core#notation
CHEBI:4317
pharm_class
Skeletal Muscle Relaxant [EPC]
upc
0364850842013
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
856698
active_ingredient_strength
20 mg/60mL
package_marketing_start_date
01-SEP-06
manufacturer_name
Elite Laboratories, Inc.
active_ingredient_name
DANTROLENE SODIUM
unii
287M0347EV
spl_set_id
11850cd6-da36-4d83-b385-0abd3122ed96
package_description
35 kg in 1 BAG (65129-1012-0)
listing_expiration_date
20241231
route
INTRAVENOUS
labeler_name
Elite Laboratories, Inc.
marketing_start_date
20060901
spl_id
4d9619ea-d238-466b-ab8e-4da53f08ef3e
package_ndc
63629-2170-1
has_treatment
http://purl.obolibrary.org/obo/DOID_8545
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111361
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect23946
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_59697
owl#annotatedSource
t217847
owl#someValuesFrom
t2999158