Discuss This Drug

obeticholic acid

CHEBI:CHEBI_43602

Definition

A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.

Chemical Information

Molecular Formula
C26H44O4
Molecular Mass
420.626
Charge
0
SMILES
C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@@H]([C@@H]([C@@]2(C[C@@H](C1)O)[H])CC)O)[H])(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)[H])C
InChI
InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
InChIKey
ZXERDUOLZKYMJM-ZWECCWDJSA-N

Alternative Names

  • (3alpha,5beta,6alpha,7alpha)-6-ethyl-3,7-dihydroxycholan-24-oic acid
  • 6-ECDCA
  • 6-Ethyl-CDCA
  • 6-Ethylchenodeoxycholic acid
  • 6alpha-ethyl-3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
  • 6alpha-Ethyl-chenodeoxycholic acid
  • 6alpha-ethylchenodeoxycholic acid
  • INT 747
  • INT-747
  • INT747
  • obeticholic acid
  • Ocaliva

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:43602
DRON_00010000
1798288
oboInOwl#hasDbXref
Wikipedia:Obeticholic_acid

Additional References

Wikipedia:Obeticholic_acid

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:43602
rxcui
1798375
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
10 kg/10kg
package_marketing_start_date
13-DEC-16
marketing_start_date
20191209
active_ingredient_name
OBETICHOLIC ACID
manufacturer_name
Intercept Pharmaceuticals Inc
spl_id
0cef86b0-d092-07bb-e063-6394a90a079d
package_ndc
73435-004-11
package_description
10 kg in 1 DRUM (73435-004-11)
unii
0462Z4S4OZ
spl_set_id
cdfbe0cd-eb15-45a1-ac17-531bcda21aec
nui
N0000192560
upc
0369516010300
pharm_class_epc
Farnesoid X Receptor Agonist [EPC]
pharm_class
Farnesoid X Receptor Agonists [MoA]
pharm_class_moa
Farnesoid X Receptor Agonists [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1798288
oboInOwl#hasDbXref
Wikipedia:Obeticholic_acid
oboInOwl#hasAlternativeId
CHEBI:43599
oboInOwl#id
CHEBI:43602
generic_name
Obeticholic acid
brand_name
Ocaliva
brand_name_base
Ocaliva
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
labeler_name
Intercept Pharmaceuticals Inc
product_ndc
73435-004
application_number
NDA207999
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62868
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_16755
has_treatment
http://purl.obolibrary.org/obo/DOID_12236
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_108652
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect24006
owl#annotatedSource
t218047
owl#someValuesFrom
t3028770