Methotrexate
CHEBI:CHEBI_44185
Chemical Information
- Molecular Formula
- C20H22N8O5
- Molecular Mass
- 454.43960
- Charge
- 0
- SMILES
- CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
- InChI
- InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
- InChIKey
- FBOZXECLQNJBKD-ZDUSSCGKSA-N
Alternative Names
- 4-amino-10-methylfolic acid
- 4-amino-N(10)-methylpteroylglutamic acid
- Emtexate
- Ledertrexate
- methotrexate
- Methotrexate
- METHOTREXATE
- methotrexatum
- metotrexato
- MTX
- N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
- N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
- Rheumatrex
- Trexall
Treatment Applications
Drug Classification
-
t217795
-
t217849
-
t217920
-
monocarboxylic acid amideView Class →
CHEBI:29347
-
dicarboxylic acidView Class →
CHEBI:35692
-
pteridinesView Class →
CHEBI:26373
-
t216811
-
t216823
-
t217212
-
t217282
-
t217456
-
t217536
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 6851
- oboInOwl#hasDbXref
- Wikipedia:Methotrexate
- core#notation
- CHEBI:44185
Additional References
Wikipedia:Methotrexate
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- listing_expiration_date
- 20241231
- route
- INTRATHECAL
- marketing_start_date
- 20000122
- spl_id
- 177124c3-1dd0-4167-9a02-2f053fe1ac85
- labeler_name
- Elite Laboratories, Inc.
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- dosage_form
- INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
- application_number
- NDA212479
- product_ndc
- 59137-525
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 6851
- oboInOwl#hasDbXref
- Wikipedia:Methotrexate
- oboInOwl#hasAlternativeId
- CHEBI:6837
- oboInOwl#id
- CHEBI:44185
- generic_name
- methotrexate sodium
- brand_name
- JYLAMVO
- brand_name_base
- JYLAMVO
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_50683
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_50680
- chebi#has_functional_parent
- http://purl.obolibrary.org/obo/CHEBI_16015
- package_ndc
- 0703-3671-01
- package_description
- 1 VIAL, SINGLE-DOSE in 1 CARTON (0703-3671-01) / 2 mL in 1 VIAL, SINGLE-DOSE
- package_marketing_start_date
- 14-JAN-10
- rxcui
- 2671462
- manufacturer_name
- SHORLA ONCOLOGY INC.
- core#notation
- CHEBI:44185
- active_ingredient_name
- 2-((4-((4-(((2,4-DIAMINOPTERIDIN-6-YL)METHYL)METHYLAMINO)BENZOYL)METHYLAMINO)BENZOYL)AMINO)PENTANEDIOIC ACID, (2S)-
- active_ingredient_strength
- 10 mg/.4mL
- pharm_class_epc
- Folate Analog Metabolic Inhibitor [EPC]
- pharm_class
- Folic Acid Metabolism Inhibitors [MoA]
- pharm_class_moa
- Folic Acid Metabolism Inhibitors [MoA]
- unii
- YL5FZ2Y5U1
- spl_set_id
- 96e931f5-51ae-4bdf-a441-bb0dd26d4c0e
- upc
- 0362135772352
- nui
- N0000000111
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_0070526
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_113495
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_50680
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect24107
- owl#annotatedSource
- t218054
- owl#someValuesFrom
- t3865841
- Treatment
- http://purl.obolibrary.org/obo/DOID_0040096
- Medication
- http://purl.obolibrary.org/obo/DOID_0040097