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Methotrexate

CHEBI:CHEBI_44185

Chemical Information

Molecular Formula
C20H22N8O5
Molecular Mass
454.43960
Charge
0
SMILES
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI
InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N

Alternative Names

  • 4-amino-10-methylfolic acid
  • 4-amino-N(10)-methylpteroylglutamic acid
  • Emtexate
  • Ledertrexate
  • methotrexate
  • Methotrexate
  • METHOTREXATE
  • methotrexatum
  • metotrexato
  • MTX
  • N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
  • N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
  • Rheumatrex
  • Trexall

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:44185
DRON_00010000
6851
oboInOwl#hasDbXref
Wikipedia:Methotrexate

Additional References

Wikipedia:Methotrexate

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
labeler_name
SHORLA ONCOLOGY INC.
application_number
NDA212479
product_ndc
59137-525
package_ndc
0703-3671-01
route
INTRA-ARTERIAL
package_description
1 VIAL, SINGLE-DOSE in 1 CARTON (0703-3671-01) / 2 mL in 1 VIAL, SINGLE-DOSE
core#notation
CHEBI:44185
rxcui
2671462
manufacturer_name
SHORLA ONCOLOGY INC.
package_marketing_start_date
20140710
listing_expiration_date
20241231
marketing_start_date
20000122
spl_id
177124c3-1dd0-4167-9a02-2f053fe1ac85
active_ingredient_name
2-((4-((4-(((2,4-DIAMINOPTERIDIN-6-YL)METHYL)METHYLAMINO)BENZOYL)METHYLAMINO)BENZOYL)AMINO)PENTANEDIOIC ACID, (2S)-
active_ingredient_strength
10 mg/.4mL
pharm_class_epc
Folate Analog Metabolic Inhibitor [EPC]
pharm_class
Folic Acid Metabolism Inhibitors [MoA]
pharm_class_moa
Folic Acid Metabolism Inhibitors [MoA]
unii
YL5FZ2Y5U1
spl_set_id
96e931f5-51ae-4bdf-a441-bb0dd26d4c0e
upc
0362135772352
nui
N0000000111
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6851
oboInOwl#hasDbXref
Wikipedia:Methotrexate
oboInOwl#hasAlternativeId
CHEBI:6837
oboInOwl#id
CHEBI:44185
generic_name
methotrexate sodium
brand_name
JYLAMVO
brand_name_base
JYLAMVO
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50683
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_50680
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_16015
Treatment
http://purl.obolibrary.org/obo/DOID_0040096
Medication
http://purl.obolibrary.org/obo/DOID_0040097
has_treatment
http://purl.obolibrary.org/obo/DOID_0111395
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113495
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_50680
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect24107
owl#annotatedSource
t218054
owl#someValuesFrom
t3865841