Discuss This Drug

desmopressin

CHEBI:CHEBI_4450

Definition

A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.

Chemical Information

Molecular Formula
C46H64N14O12S2
Molecular Mass
1069.21700
Charge
0
SMILES
NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
InChI
InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1
InChIKey
NFLWUMRGJYTJIN-PNIOQBSNSA-N

Alternative Names

  • 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin
  • 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
  • 1-deamino-8-D-arginine vasopressin
  • 1-desamino-8-D-arginine vasopressin
  • DDAVP
  • desmopresina
  • desmopressin
  • desmopressine
  • desmopressinum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:4450
DRON_00010000
3251
oboInOwl#hasDbXref
KEGG:D00291

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:4450
pharm_class
Vasopressin Analog [EPC]
upc
0368001575003
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
listing_expiration_date
20241231
route
NASAL
spl_id
e17d40ea-c4b8-4646-8597-1f9c33031bec
package_ndc
41701-007-15
marketing_start_date
20140220
package_description
1 BOTTLE, PLASTIC in 1 BOTTLE, PLASTIC (41701-007-15) / 25 g in 1 BOTTLE, PLASTIC (41701-007-14)
rxcui
1723234
active_ingredient_strength
80 g/80g
active_ingredient_name
DESMOPRESSIN
unii
XB13HYU18U
spl_set_id
539d7da2-72b8-45f9-836c-4e3351dd488e
manufacturer_name
XGen Pharmaceuticals DJB, Inc.
package_marketing_start_date
20-MAR-17
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3251
oboInOwl#hasDbXref
KEGG:D00291
oboInOwl#id
CHEBI:4450
brand_name
Desmopressin acetate
brand_name_base
Desmopressin acetate
generic_name
Desmopressin acetate
product_ndc
35207-0001
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_59727
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
product_type
BULK INGREDIENT
marketing_category
EXPORT ONLY
dosage_form
SPRAY
labeler_name
Hybio Pharmaceutical Co., Ltd.
application_number
ANDA215961
has_treatment
http://purl.obolibrary.org/obo/DOID_578
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113616
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect24192
owl#annotatedSource
t217819
owl#someValuesFrom
t3019319