Discuss This Drug

Ritonavir

CHEBI:CHEBI_45409

Definition

An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.

Chemical Information

Molecular Formula
C37H48N6O5S2
Molecular Mass
720.94400
Charge
0
SMILES
CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
InChI
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChIKey
NCDNCNXCDXHOMX-XGKFQTDJSA-N

Alternative Names

  • N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
  • ritonavir

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
85762
oboInOwl#hasDbXref
Wikipedia:Ritonavir
core#notation
CHEBI:45409

Additional References

Wikipedia:Ritonavir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
package_marketing_start_date
01-MAR-96
marketing_start_date
20240822
spl_id
eeb20aab-f62a-4d80-92d1-2d6b3e2a5758
package_ndc
69097-655-08
package_description
120 TABLET in 1 CONTAINER (69097-655-08)
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
85762
oboInOwl#hasDbXref
Wikipedia:Ritonavir
oboInOwl#id
CHEBI:45409
oboInOwl#hasAlternativeId
CHEBI:8873
generic_name
ritonavir 100 mg
brand_name
Ritonavir film coated
brand_name_base
Norvir
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
POWDER
labeler_name
AbbVie Deutschland GmbH & Co Kg
product_ndc
69097-655
application_number
ANDA202573
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35660
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723854
core#notation
CHEBI:45409
rxcui
1926069
active_ingredient_strength
50 kg/50kg
pharm_class_moa
UDP Glucuronosyltransferases Inducers [MoA]
pharm_class
UDP Glucuronosyltransferases Inducers [MoA]
nui
N0000190117
manufacturer_name
Cipla USA Inc.
active_ingredient_name
RITONAVIR
pharm_class_epc
Protease Inhibitor [EPC]
unii
O3J8G9O825
spl_set_id
4633c6ba-168d-426f-acae-7843e167743a
upc
0369097655020
brand_name_suffix
film coated
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6045
owl#annotatedSource
t221492
owl#someValuesFrom
t3037554