imatinib

CHEBI:CHEBI_45783

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.

Chemical Information

Molecular Formula: C29H31N7O
Molecular Mass: 493.60270
Charge: 0
SMILES: CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChIKey: KTUFNOKKBVMGRW-UHFFFAOYSA-N

Alternative Names

4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
imatinib
STI 571

Treatment Applications

Carney-Stratakis syndrome
DOID:0080533

View Disease →
obsolete malignant mesenchymal neoplasm of the stomach
DOID:5281

View Disease →

Drug Classification

benzamides
CHEBI:22702

View Class →
pyrimidines
CHEBI:39447

View Class →
pyridines
CHEBI:26421

View Class →
aromatic amine
CHEBI:33860

View Class →
N-methylpiperazine
CHEBI:46920

View Class →
t221046
t221228
t221314
t221490

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000: 282388
oboInOwl#hasDbXref: Wikipedia:Imatinib
core#notation: CHEBI:45783

Additional References

Wikipedia:Imatinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_description: 18 kg in 1 DRUM (62068-309-02)
package_ndc: 72485-202-90
oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 282388
oboInOwl#hasDbXref: Wikipedia:Imatinib
oboInOwl#hasAlternativeId: CHEBI:45781
oboInOwl#id: CHEBI:45783
generic_name: IMATINIB BASE
brand_name: Imatinib mesylate 400 mg
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_68495
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent: http://purl.obolibrary.org/obo/CHEBI_28179
brand_name_base: Gleevec
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT
dosage_form: POWDER
labeler_name: Valary Lab Private Limited
product_ndc: 62068-309
application_number: ANDA204285
has_treatment: http://purl.obolibrary.org/obo/DOID_2668
listing_expiration_date: 20241231
marketing_start_date: 20030518
spl_id: 5c50ce9c-60b0-4293-a6f9-72cd302949a7
route: ORAL
package_marketing_start_date: 10-MAR-15
manufacturer_name: Mylan Pharmaceuticals Inc.
core#notation: CHEBI:45783
rxcui: 404589
active_ingredient_strength: 640 kg/640kg
pharm_class: Bcr-Abl Tyrosine Kinase Inhibitors [MoA]
active_ingredient_name: IMATINIB
unii: 8A1O1M485B
spl_set_id: a819a954-41c9-4d49-a74e-c8c4b338b22a
upc: 0372485203307
brand_name_suffix: 400 mg
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_111447
rdf-schema#domain: https://w3id.org/def/predibionto#has_side_effect24598
owl#annotatedSource: t221501
owl#someValuesFrom: t947388