Paclitaxel
CHEBI:CHEBI_45863
Definition
A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical Information
- Molecular Formula
- C47H51NO14
- Molecular Mass
- 853.90618
- Charge
- 0
- SMILES
- [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C
- InChI
- InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
- InChIKey
- RCINICONZNJXQF-MZXODVADSA-N
Alternative Names
- 4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
- 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
- Paclitaxel
- taxol
- TAXOL
- Taxol A
- (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
Drug Classification
-
tetracyclic diterpenoidView Class →
CHEBI:52557
-
taxane diterpenoidView Class →
CHEBI:50367
-
t220473
-
t220590
-
t221064
-
t221353
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 56946
- oboInOwl#hasDbXref
- Wikipedia:Paclitaxel
- core#notation
- CHEBI:45863
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
- listing_expiration_date
- 20241231
- marketing_start_date
- 19990422
- labeler_name
- Yunnan Hande Bio-Tech Co., Ltd.
- application_number
- NDA211875
- spl_id
- 123ca118-22d1-4505-a067-f5a157242e16
- route
- INTRAVENOUS
- package_ndc
- 65129-1308-0
- package_description
- 6 kg in 1 BAG (65129-1308-0)
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 56946
- oboInOwl#hasDbXref
- Wikipedia:Paclitaxel
- oboInOwl#hasAlternativeId
- CHEBI:7887
- oboInOwl#id
- CHEBI:45863
- generic_name
- Paclitaxel Semisynthetic
- brand_name
- PACLITAXEL PROTEIN BOUND PARTICLES ALBUMIN BOUND
- brand_name_base
- PACLITAXEL PROTEIN BOUND PARTICLES ALBUMIN BOUND
- dosage_form
- INJECTION, POWDER, FOR SOLUTION
- product_ndc
- 65129-1308
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_61950
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#has_functional_parent
- http://purl.obolibrary.org/obo/CHEBI_32898
- core#notation
- CHEBI:45863
- rxcui
- 583218
- active_ingredient_name
- PACLITAXEL
- brand_name_suffix
- PACLITAXEL
- active_ingredient_strength
- 4 kg/4kg
- unii
- P88XT4IS4D
- spl_set_id
- 4e1bf850-d616-4ff3-b62a-2057dddc3dfe
- nui
- N0000175592
- pharm_class_epc
- Microtubule Inhibitor [EPC]
- pharm_class
- Microtubule Inhibition [PE]
- pharm_class_pe
- Microtubule Inhibition [PE]
- upc
- 0372205062016
- manufacturer_name
- Hospira, Inc.
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- package_marketing_start_date
- 14-JAN-15
- has_treatment
- http://purl.obolibrary.org/obo/DOID_8602
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect24604
- owl#annotatedSource
- t221352
- owl#someValuesFrom
- t2916200