Discuss This Drug

Trimethoprim

CHEBI:CHEBI_45924

Definition

An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.

Chemical Information

Molecular Formula
C14H18N4O3
Molecular Mass
290.318
Charge
0
SMILES
C=1(CC=2C(=NC(N)=NC2)N)C=C(C(OC)=C(C1)OC)OC
InChI
InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChIKey
IEDVJHCEMCRBQM-UHFFFAOYSA-N

Alternative Names

  • 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
  • 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
  • 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine
  • Proloprim
  • Trimethoprim
  • TRIMETHOPRIM
  • Trimpex

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Trimethoprim
DRON_00010000
10829
core#notation
CHEBI:45924

Additional References

Wikipedia:Trimethoprim

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Trimethoprim
DRON_00010000
10829
oboInOwl#hasAlternativeId
CHEBI:9731
prefixIRI
CHEBI:45924
oboInOwl#id
CHEBI:45924
generic_name
Trimethoprim sulfate and Polymyxin B sulfate
brand_name
Trimethoprim sulfate and Polymyxin B sulfate
brand_name_base
Trimethoprim sulfate and Polymyxin B sulfate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
SOLUTION
labeler_name
Andhra Organics Limited
product_ndc
62991-3173
application_number
ANDA091437
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50683
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
listing_expiration_date
20241231
route
OPHTHALMIC
package_marketing_start_date
04-MAR-22
marketing_start_date
20120216
spl_id
2b6f8286-7d37-4c17-84a6-25865536ea12
package_ndc
62991-3173-3
package_description
25000 g in 1 DRUM (62991-3173-3)
core#notation
CHEBI:45924
active_ingredient_name
TRIMETHOPRIM SULFATE
rxcui
244967
manufacturer_name
Mayne Pharma
active_ingredient_strength
25 kg/25kg
nui
N0000187062
pharm_class_moa
Cytochrome P450 2C8 Inhibitors [MoA]
pharm_class
Dihydrofolate Reductase Inhibitor Antibacterial [EPC]
unii
E377MF8EQ8
pharm_class_epc
Dihydrofolate Reductase Inhibitor Antibacterial [EPC]
spl_set_id
249e938d-f181-47c4-a082-372d65462f33
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2381
owl#someValuesFrom
t712752
RO_0001022
http://purl.obolibrary.org/obo/DOID_0040029
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect386
owl#annotatedSource
t221499