Discuss This Drug

Dimenhydrinate

CHEBI:CHEBI_4604

Definition

The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention and treatment of motion sickness.

Chemical Information

Molecular Formula
C24H28ClN5O3
Molecular Mass
469.96400
Charge
0
SMILES
Cn1c2nc(Cl)[n-]c2c(=O)n(C)c1=O.C[NH+](C)CCOC(c1ccccc1)c1ccccc1
InChI
InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10,13)
InChIKey
DKHVTDUUNTVKOW-UHFFFAOYSA-N

Alternative Names

  • (O-benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate
  • 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-ide
  • 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
  • Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline
  • beta-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine
  • dimenhidrinato
  • dimenhydrinate
  • dimenhydrinatum
  • diphenhydramine 8-chlorotheophyllinate
  • diphenhydramine 8-chlorotheophylline
  • diphenhydramine theoclate
  • N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate
  • O-benzhydryldimethylaminoethanol 8-chlorotheophyllinate

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3444
oboInOwl#hasDbXref
Patent:US2534813
core#notation
CHEBI:4604

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3444
oboInOwl#hasDbXref
Patent:US2534813
oboInOwl#id
CHEBI:4604
generic_name
DIMENHYDRINATE
brand_name
Dramamine Orange
brand_name_base
Dramamine Orange
dosage_form
SYRUP
product_ndc
12711-4675
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59778
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_37955
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20050311
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
labeler_name
Shanghai Wonder Pharmaceutical Co. Ltd.
application_number
part336
spl_id
4d532d33-35fd-4cbf-a0d3-1d07050d64a8
package_ndc
12711-4675-0
core#notation
CHEBI:4604
package_marketing_start_date
10-AUG-16
package_description
25 kg in 1 DRUM (12711-4675-0)
rxcui
2594768
active_ingredient_strength
15 mg/5mL
pharm_class
Histamine-1 Receptor Antagonist [EPC]
manufacturer_name
Cardinal Health
active_ingredient_name
DIMENHYDRINATE
unii
JB937PER5C
spl_set_id
ace7eba4-e033-48f5-8533-c3ea9dfc32b0
upc
0681131065740
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2951
owl#annotatedSource
t221542
owl#someValuesFrom
t2996737