Discuss This Drug

Fluorouracil

CHEBI:CHEBI_46345

Definition

A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Chemical Information

Molecular Formula
C4H3FN2O2
Molecular Mass
130.07730
Charge
0
SMILES
Fc1c[nH]c(=O)[nH]c1=O
InChI
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKey
GHASVSINZRGABV-UHFFFAOYSA-N

Alternative Names

  • 5-Fluoracil
  • 5-Fluoropyrimidine-2,4-dione
  • 5-fluoropyrimidine-2,4(1H,3H)-dione
  • 5-fluorouracil
  • 5-Fluorouracil
  • 5-FU
  • fluorouracil
  • Fluorouracil
  • fluorouracilo
  • fluorouracilum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Fluorouracil
DRON_00010000
4492
core#notation
CHEBI:46345

Additional References

Wikipedia:Fluorouracil

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_marketing_start_date
13-DEC-10
package_description
1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON (63323-117-61) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE
package_ndc
62991-1486-5
rxcui
1669873
active_ingredient_strength
2 g/40g
nui
N0000175595
manufacturer_name
HILL DERMACEUTICALS, INC.
active_ingredient_name
FLUOROURACIL
unii
U3P01618RT
spl_set_id
beb8c6c5-4b6e-4770-b6d4-718e33c7a2ff
upc
0363323117511
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Fluorouracil
DRON_00010000
4492
generic_name
FLUOROURACIL
oboInOwl#hasAlternativeId
CHEBI:46343
oboInOwl#id
CHEBI:46345
brand_name
TOLAK
brand_name_base
TOLAK
dosage_form
INJECTION, SOLUTION
product_ndc
62991-1486
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35703
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_17568
core#notation
CHEBI:46345
pharm_class_moa
Nucleic Acid Synthesis Inhibitors [MoA]
pharm_class
Nucleoside Metabolic Inhibitor [EPC]
pharm_class_epc
Nucleoside Metabolic Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
route
INTRAVENOUS
spl_id
03b13997-fea4-e33a-e063-6294a90a19eb
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
marketing_start_date
20101213
labeler_name
Bozhou Kunyu Biotechnology Co., Ltd.
application_number
ANDA076526
has_treatment
http://purl.obolibrary.org/obo/DOID_3168
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_110234
owl#annotatedSource
t224950
owl#someValuesFrom
t3001259