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Fluorouracil

CHEBI:CHEBI_46345

Definition

A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Chemical Information

Molecular Formula
C4H3FN2O2
Molecular Mass
130.07730
Charge
0
SMILES
Fc1c[nH]c(=O)[nH]c1=O
InChI
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKey
GHASVSINZRGABV-UHFFFAOYSA-N

Alternative Names

  • 5-Fluoracil
  • 5-Fluoropyrimidine-2,4-dione
  • 5-fluoropyrimidine-2,4(1H,3H)-dione
  • 5-fluorouracil
  • 5-Fluorouracil
  • 5-FU
  • fluorouracil
  • Fluorouracil
  • fluorouracilo
  • fluorouracilum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Fluorouracil
DRON_00010000
4492
core#notation
CHEBI:46345

Additional References

Wikipedia:Fluorouracil

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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