Discuss This Drug

dorzolamide

CHEBI:CHEBI_4702

Definition

5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.

Chemical Information

Molecular Formula
C10H16N2O4S3
Molecular Mass
324.44000
Charge
0
SMILES
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI
InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChIKey
IAVUPMFITXYVAF-XPUUQOCRSA-N

Alternative Names

  • (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
  • (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • (4S,6S)-4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
  • (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
  • 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
  • 4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide
  • 4S,6S-dorzolamide
  • dorzolamide
  • Dorzolamide
  • DORZOLAMIDE

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
60207
oboInOwl#hasDbXref
Wikipedia:Dorzolamide
core#notation
CHEBI:4702

Additional References

Wikipedia:Dorzolamide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
marketing_start_date
20191201
route
OPHTHALMIC
spl_id
511d4919-0475-4719-8841-a0df9b838b34
package_ndc
62332-553-10
package_description
1 BOTTLE in 1 CARTON (62332-553-10) / 10 mL in 1 BOTTLE
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
60207
oboInOwl#hasDbXref
Wikipedia:Dorzolamide
oboInOwl#hasAlternativeId
CHEBI:42295
oboInOwl#id
CHEBI:4702
generic_name
Dorzolamide hydrochloride and timolol maleate
brand_name
Dorzolamide hydrochloride and timolol maleate
brand_name_base
Dorzolamide hydrochloride and timolol maleate
product_ndc
62332-553
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_23018
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rxcui
1923433
package_marketing_start_date
20100102
manufacturer_name
Thea Pharma Inc.
unii
QZO5366EW7
spl_set_id
6b9c446e-7068-479b-8611-aead7a8d2f50
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
SOLUTION/ DROPS
labeler_name
Thea Pharma Inc.
application_number
ANDA217260
core#notation
CHEBI:4702
pharm_class
Carbonic Anhydrase Inhibitors [MoA]
active_ingredient_strength
22.3 mg/mL
active_ingredient_name
DORZOLAMIDE HYDROCHLORIDE
upc
0314445405109
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0070517
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_105692
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect25161
owl#annotatedSource
t224859
owl#someValuesFrom
t543457