doxacurium
CHEBI:CHEBI_4706
Definition
A mixture of the (1R,2S,1'S,2'R), (1R,2S,1'R,2'S) and (1S,2R,1'S,2'R) stereoisomers (a meso isomer and two enantiomers, respectively) of 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxypropane-3,1-diyl)]bis[6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium], all of which are in a trans configuration at the 1 and 2 positions of the tetrahydroisoquinolinium rings. A competitive neuromuscular blocker, the chloride salt is used to provide muscle relaxation in general anaesthesia and to facilitate mechanical ventilation in patients in intensive care.
Chemical Information
- Molecular Formula
- C56H78N2O16
- Molecular Mass
- 1035.224
- Charge
- 0
Alternative Names
- Doxacurium
- (1R,2S;1S,2R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium, succinate (2:1), mixture with (+-)-(1R*,2S*;1R*,2S*)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium, succinate (2:1)
Drug Classification
-
quaternary ammonium ionView Class →
CHEBI:35267
-
diesterView Class →
CHEBI:51307
-
t223615
-
t223797
-
t224618
-
t224724
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 23651
- core#notation
- CHEBI:4706
- oboInOwl#hasDbXref
- KEGG:C07549
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect25162
- owl#annotatedSource
- t224322
- owl#someValuesFrom
- t512560
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 23651
- oboInOwl#id
- CHEBI:4706
- core#notation
- CHEBI:4706
- oboInOwl#hasDbXref
- KEGG:C07549
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_51371
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- BFO_0000051
- http://purl.obolibrary.org/obo/CHEBI_59822
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class