Discuss This Drug

lonafarnib

CHEBI:CHEBI_47097

Definition

A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase inhibitor.

Chemical Information

Molecular Formula
C27H31Br2ClN4O2
Molecular Mass
638.822
Charge
0
SMILES
C=12CCC=3C=C(C=C(C3[C@H](C1N=CC(=C2)Br)C4CCN(CC4)C(=O)CC5CCN(CC5)C(N)=O)Br)Cl
InChI
InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChIKey
DHMTURDWPRKSOA-RUZDIDTESA-N

Alternative Names

  • 4-(2-{4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide
  • lonafarnib
  • lonafarnibum
  • SCH 66336

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:47097
DRON_00010000
2467553
oboInOwl#hasDbXref
Wikipedia:Lonafarnib

Additional References

Wikipedia:Lonafarnib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:47097
pharm_class
Farnesyltransferase Inhibitors [MoA]
pharm_class_moa
Cytochrome P450 2C8 Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3911
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect25200
owl#annotatedSource
t224915
owl#someValuesFrom
t3736090
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2467553
oboInOwl#hasDbXref
Wikipedia:Lonafarnib
oboInOwl#id
CHEBI:47097
generic_name
Lonafarnib
rxcui
2467592
brand_name
Zokinvy
brand_name_base
Zokinvy
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
dosage_form
CAPSULE
active_ingredient_strength
1 mg/500mg
nui
N0000193939
marketing_start_date
20201120
labeler_name
Eiger BioPharmaceuticals, Inc.
package_marketing_start_date
20-NOV-20
product_ndc
73079-050
application_number
NDA213969
manufacturer_name
Eiger BioPharmaceuticals, Inc.
spl_id
01f61740-d196-4d18-e063-6394a90a4ae5
active_ingredient_name
LONAFARNIB
package_ndc
73079-050-30
package_description
1 BOTTLE, PLASTIC in 1 CARTON (73079-050-30) / 30 CAPSULE in 1 BOTTLE, PLASTIC
unii
IOW153004F
spl_set_id
956a142f-35d6-4fe3-8aef-7e4878d275ed
upc
0373079075300
pharm_class_epc
Farnesyltransferase Inhibitor [EPC]
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_64133
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR