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Droperidol

CHEBI:CHEBI_4717

Definition

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.

Chemical Information

Molecular Formula
C22H22FN3O2
Molecular Mass
379.42740
Charge
0
SMILES
Fc1ccc(cc1)C(=O)CCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O
InChI
InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
InChIKey
RMEDXOLNCUSCGS-UHFFFAOYSA-N

Alternative Names

  • 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
  • 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
  • 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
  • droperidol
  • droperidolum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3648
oboInOwl#hasDbXref
Wikipedia:Droperidol
core#notation
CHEBI:4717

Additional References

Wikipedia:Droperidol

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3648
oboInOwl#hasDbXref
Wikipedia:Droperidol
oboInOwl#hasAlternativeId
CHEBI:252751
oboInOwl#id
CHEBI:4717
generic_name
DROPERIDOL
rxcui
2603284
product_type
BULK INGREDIENT
listing_expiration_date
20241231
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
route
INTRAVENOUS
labeler_name
GRINDEKS Joint Stock Company
manufacturer_name
Hikma Pharmaceuticals USA Inc.
pharm_class_moa
Dopamine D2 Antagonists [MoA]
pharm_class
Dopamine-2 Receptor Antagonist [EPC]
pharm_class_epc
Dopamine-2 Receptor Antagonist [EPC]
marketing_start_date
20090716
package_marketing_start_date
16-JUL-09
active_ingredient_strength
2.5 mg/mL
nui
N0000175799
brand_name
DROPERIDOL
brand_name_base
DROPERIDOL
active_ingredient_name
DROPERIDOL
product_ndc
64189-0601
application_number
ANDA208197
spl_id
27c291c3-aa23-97af-e063-6394a90a6565
package_ndc
64189-0601-3
package_description
1 BAG in 1 BAG (64189-0601-3) / 30 kg in 1 BAG
unii
O9U0F09D5X
spl_set_id
d89f33ac-8a6e-49e7-94fb-84e58aad65a8
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_60807
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:4717
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_14165
owl#annotatedSource
t224944
owl#someValuesFrom
t2996854